{"entity":{"id":"nr4a3","kind":"target","name":"NR4A3","aka":["nuclear receptor subfamily 4 group A member 3","Nuclear receptor subfamily 4 group A member 3","NOR1","MINOR"],"tldr":"NR4A3 (Nuclear receptor subfamily 4 group A member 3) is a protein that switches other genes on and off. The public catalogues list it as a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Sarcomas, Colorectal cancer, Lung cancer and 1 more.","summary":"Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner. Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes. Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation.\n\nCIViC holds 1 clinical evidence item and 1 assertion across 3 variants. Open Targets scores its association with cancer at 0.73 (direct and indirect evidence; datatypes genetic literature 0.61, literature 0.97, genetic association 0.33, somatic mutation 0.98, animal model 0.34).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7982","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7982"},{"label":"UniProt Q92570","url":"https://www.uniprot.org/uniprotkb/Q92570/entry"},{"label":"NCBI Gene 8013","url":"https://www.ncbi.nlm.nih.gov/gene/8013"},{"label":"Ensembl ENSG00000119508","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000119508"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets"],"cancers":["sarcoma","colorectal","lung-cancer","chondrosarcoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Acinic Cell Carcinoma."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"NR4A3","role":["biomarker","fusion-partner"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:7982","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7982","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q92570","url":"https://www.uniprot.org/uniprotkb/Q92570/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene NR4A3","url":"https://civicdb.org/features/6415","note":"1 evidence items, 1 assertions, 3 variants; diseases: Acinic Cell Carcinoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000119508","url":"https://platform.opentargets.org/target/ENSG00000119508/associations","note":"association with cancer (MONDO_0004992) 0.73; per-cancer scores at or above 0.5: colorectal cancer 0.52, sarcoma 0.67, lung cancer 0.51, chondrosarcoma 0.54 (GraphQL API, CC0)"}],"specificity":"tumour-specific","distribution":"few-types","specificityNote":"Tumour-specific alteration: the catalogues call it a fusion partner (UniProt records a translocation); what a medicine would aim at or exploit is the altered form or its loss, absent from normal cells; no corpus medicine is aimed at it yet. HPA NR4A3: RNA low tissue specificity; no normal tissue stained high; highest cancer staining liver cancer (2 of 10 high). Distribution: 3 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Sarcomas (soft tissue, bone, GIST), Colorectal cancer, Lung cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 6 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"UniProt Q92570","url":"https://www.uniprot.org/uniprotkb/Q92570/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene NR4A3","url":"https://civicdb.org/features/6415","note":"1 evidence items, 1 assertions, 3 variants; diseases: Acinic Cell Carcinoma (GraphQL API, CC0)"},{"label":"Human Protein Atlas NR4A3 tissue","url":"https://www.proteinatlas.org/ENSG00000119508-NR4A3/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000119508 associations","url":"https://platform.opentargets.org/target/ENSG00000119508/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:7982","ensembl":"ENSG00000119508","uniprot":"Q92570","entrez":"8013","firstDescribed":1995,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Hedvat C.V. et al, Mol. Endocrinol, 1995, \"The isolation and characterization of MINOR, a novel mitogen-inducible nuclear orphan receptor\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/8614405/","biology":"Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner. Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes. Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation. Mediates proliferation of vascular smooth muscle, myeloid progenitor cell and type B pancreatic cells; promotes mitogen-induced vascular smooth muscle cell proliferation through transactivation of SKP2 promoter by binding a NBRE site. Upon PDGF stimulation, stimulates vascular smooth muscle cell proliferation by regulating CCND1 and CCND2 expression. In islets, induces type B pancreatic cell proliferation through up-regulation of genes that activate cell cycle, as well as genes that cause degradation of the CDKN1A. Location: Nucleus (UniProt). Locus 9q31.1 (HGNC).","whereFound":["Sarcomas: Open Targets association 0.67 with sarcoma (MONDO_0005089)","Colorectal cancer: Open Targets association 0.52 with colorectal cancer (MONDO_0005575)","Lung cancer: Open Targets association 0.51 with lung cancer (MONDO_0008903)","Chondrosarcoma: Open Targets association 0.54 with chondrosarcoma (MONDO_0008977)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/nr4a3/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"chondrosarcoma","kind":"cancer","name":"Chondrosarcoma","route":"/cancers/chondrosarcoma/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"}]}}