{"entity":{"id":"noopur-raje","kind":"person","name":"Noopur Raje","aka":[],"tldr":"Led the first-in-human trial of BCMA CAR-T (bb2121) in myeloma and studies of bone disease treatment.","summary":"Noopur Raje led the first-in-human trial of bb2121 (idecabtagene vicleucel), which showed deep responses in heavily pretreated myeloma and launched BCMA-directed CAR-T therapy, and the trial establishing denosumab as an alternative to zoledronic acid for myeloma bone disease. She directs the myeloma centre at MGH and leads trials of bispecifics and next-generation cell therapies.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Raje%20N%5BAuthor%5D%20myeloma%20BCMA"}],"tags":["myeloma","car-t","bone-disease"],"related":[],"cancers":["multiple-myeloma"],"sections":[],"technologies":["car-t"],"targets":["bcma"],"drugs":[],"companies":[],"institutions":["mgh"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":["paper-karmma-3-ide-cel-nejm-2023"],"journals":[],"dependsOn":[],"notes":[],"role":"Director, Center for Multiple Myeloma, Massachusetts General Hospital Cancer Center","institutionId":"mgh","specialisms":["Multiple myeloma","CAR T-cell therapy","Bone disease","Novel agents"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Raje%20N%5BAuthor%5D%20myeloma%20BCMA"}],"papers":[{"title":"Anti-BCMA CAR T-cell therapy bb2121 in relapsed or refractory multiple myeloma","journal":"NEJM","year":2019,"doi":"10.1056/NEJMoa1817226"},{"title":"Denosumab versus zoledronic acid in bone disease treatment of newly diagnosed multiple myeloma: an international, double-blind, double-dummy, randomised, controlled, phase 3 study","journal":"Lancet Oncology","year":2018,"doi":"10.1016/S1470-2045(18)30072-X"},{"title":"KarMMa-3: ide-cel CAR-T versus standard regimens in triple-class-exposed relapsed myeloma","journal":"New England Journal of Medicine","year":2023,"url":"https://doi.org/10.1056/NEJMoa2213614","doi":"10.1056/NEJMoa2213614"}]},"route":"/people/noopur-raje/","neighbours":{"cancer":[{"id":"multiple-myeloma","kind":"cancer","name":"Multiple myeloma","route":"/cancers/multiple-myeloma/"}],"technology":[{"id":"car-t","kind":"technology","name":"CAR-T cell therapy","route":"/technologies/car-t/"}],"target":[{"id":"bcma","kind":"target","name":"BCMA","route":"/targets/bcma/"}],"institution":[{"id":"mgh","kind":"institution","name":"Massachusetts General Hospital Cancer Center","route":"/institutions/mgh/"}],"paper":[{"id":"paper-karmma-3-ide-cel-nejm-2023","kind":"paper","name":"KarMMa-3: ide-cel CAR-T versus standard regimens in triple-class-exposed relapsed myeloma","route":"/key-papers/paper-karmma-3-ide-cel-nejm-2023/"}]}}