{"entity":{"id":"nmibc-vs-mibc","kind":"term","name":"Non-muscle-invasive vs muscle-invasive bladder cancer (NMIBC / MIBC)","aka":["muscle invasive","MIBC","non-muscle-invasive","non-muscle invasive","NMIBC","NMIBC risk group","high-risk NMIBC","T1 high-grade","BCG-naive","BCG-exposed","muscle-invasive"],"tldr":"Bladder cancer is divided by whether it has grown into the bladder's muscle wall. Before that, it is treated inside the bladder; after, the bladder is usually removed or irradiated.","summary":"NMIBC (~75% at diagnosis: Ta, T1, CIS) is managed with TURBT and intravesical therapy, stratified as low, intermediate, or high risk. MIBC (T2-T4) needs radical cystectomy or trimodality bladder preservation, now with perioperative systemic therapy (NIAGARA, EV-303/304). Metastatic disease is treated systemically. Upper-tract urothelial carcinoma (renal pelvis, ureter) shares biology and most drugs.","asOf":"2026-09-07","wikipedia":"https://en.wikipedia.org/wiki/Bladder_cancer","links":[{"label":"ClinicalTrials.gov NCT03732677: NIAGARA","url":"https://clinicaltrials.gov/study/NCT03732677"},{"label":"ClinicalTrials.gov NCT04660344: IMvigor011","url":"https://clinicaltrials.gov/study/NCT04660344"}],"tags":[],"related":["turbt","cystectomy","intravesical-therapy","organ-preservation"],"cancers":["urothelial"],"sections":["surgery"],"technologies":["cystoscopy-turbt","bcg-and-intravesical-therapy"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["niagara","imvigor011"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Clinical"},"route":"/terms/nmibc-vs-mibc/","neighbours":{"term":[{"id":"intravesical-therapy","kind":"term","name":"Intravesical therapy (BCG and bladder instillations)","route":"/terms/intravesical-therapy/"},{"id":"organ-preservation","kind":"term","name":"Organ preservation (watch-and-wait, bladder-sparing, larynx preservation)","route":"/terms/organ-preservation/"},{"id":"cystectomy","kind":"term","name":"Radical cystectomy","route":"/terms/cystectomy/"},{"id":"turbt","kind":"term","name":"Transurethral resection of bladder tumour (TURBT)","route":"/terms/turbt/"}],"cancer":[{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"}],"section":[{"id":"surgery","kind":"section","name":"Surgery & Interventional","route":"/fronts/surgery/"}],"technology":[{"id":"cystoscopy-turbt","kind":"technology","name":"Cystoscopy, blue-light imaging & TURBT","route":"/technologies/cystoscopy-turbt/"},{"id":"bcg-and-intravesical-therapy","kind":"technology","name":"Intravesical therapy (BCG, chemotherapy, devices, gene and viral therapy)","route":"/technologies/bcg-and-intravesical-therapy/"}],"trial":[{"id":"imvigor011","kind":"trial","name":"IMvigor011","route":"/trials/imvigor011/"},{"id":"niagara","kind":"trial","name":"NIAGARA","route":"/trials/niagara/"},{"id":"potomac","kind":"trial","name":"POTOMAC","route":"/trials/potomac/"}],"drug":[{"id":"bcg-intravesical","kind":"drug","name":"Intravesical BCG","route":"/drugs/bcg-intravesical/"}]}}