{"entity":{"id":"nirali-shah","kind":"person","name":"Nirali N. Shah","aka":[],"tldr":"Nirali Shah developed CD22 CAR-T for children whose leukaemia escaped CD19 therapy.","summary":"Nirali N. Shah is Head of the Hematologic Malignancies Section in the Pediatric Oncology Branch at the National Cancer Institute. She is a paediatric leukaemia specialist known for developing CD22-directed CAR-T for children whose acute lymphoblastic leukaemia escaped CD19 therapy, addressing CD19-negative relapse after tisagenlecleucel and blinatumomab. Her selected paper reports that CD22-targeted CAR T cells induce remission in B-cell acute lymphoblastic leukaemia that is naive or resistant to CD19-targeted CAR immunotherapy. She leads paediatric CAR-T trials at NCI.","asOf":"2026-09-08","wikipedia":"https://en.wikipedia.org/wiki/Nirali_N._Shah","links":[{"label":"NCI CCR profile","url":"https://ccr.cancer.gov/staff-directory/nirali-n-shah"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Shah%20NN%5BAuthor%5D"}],"tags":[],"related":[],"cancers":["all-leukemia"],"sections":[],"technologies":["car-t"],"targets":["cd22","cd19"],"drugs":[],"companies":[],"institutions":["nci"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Head, Hematologic Malignancies Section, Pediatric Oncology Branch","institutionId":"nci","specialisms":["Paediatric leukaemia","CAR-T","CD22"],"profiles":[{"label":"NCI CCR profile","url":"https://ccr.cancer.gov/staff-directory/nirali-n-shah"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Shah%20NN%5BAuthor%5D"}],"papers":[{"title":"CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy","journal":"Nature Medicine","year":2018,"url":"https://doi.org/10.1038/nm.4441","doi":"10.1038/nm.4441"}]},"route":"/people/nirali-shah/","neighbours":{"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"}],"technology":[{"id":"car-t","kind":"technology","name":"CAR-T cell therapy","route":"/technologies/car-t/"}],"target":[{"id":"cd19","kind":"target","name":"CD19","route":"/targets/cd19/"},{"id":"cd22","kind":"target","name":"CD22","route":"/targets/cd22/"}],"institution":[{"id":"nci","kind":"institution","name":"National Cancer Institute (NIH)","route":"/institutions/nci/"},{"id":"nci-ccr","kind":"institution","name":"NCI Center for Cancer Research (intramural programme)","route":"/institutions/nci-ccr/"}]}}