{"entity":{"id":"nickolas-papadopoulos","kind":"person","name":"Nickolas Papadopoulos","aka":[],"tldr":"Co-developed CancerSEEK, the blood test that showed multi-cancer early detection is possible, and ran the first prospective screening study of it.","summary":"Nickolas Papadopoulos co-led with Bert Vogelstein and Kenneth Kinzler the development of CancerSEEK, the blood test combining ctDNA mutations and protein markers that detected eight cancer types, and the DETECT-A study, the first prospective trial to show a blood test can find cancers in asymptomatic women and lead to curative surgery. He co-founded Thrive (now part of Exact Sciences) and discovered mismatch repair genes with the Hopkins group.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Papadopoulos%20N%5BAuthor%5D%20CancerSEEK%20OR%20liquid%20biopsy"}],"tags":["early-detection","liquid-biopsy","mced"],"related":[],"cancers":[],"sections":[],"technologies":["mced","liquid-biopsy"],"targets":[],"drugs":[],"companies":[],"institutions":["johns-hopkins"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":["paper-detect-a-science-2020"],"journals":[],"dependsOn":[],"notes":[],"role":"Professor of Oncology and Pathology, Ludwig Center and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins","institutionId":"johns-hopkins","specialisms":["Early cancer detection","Liquid biopsy","Cancer genetics","Multi-cancer screening"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Papadopoulos%20N%5BAuthor%5D%20CancerSEEK%20OR%20liquid%20biopsy"}],"papers":[{"title":"Detection and localization of surgically resectable cancers with a multi-analyte blood test (CancerSEEK)","journal":"Science","year":2018,"doi":"10.1126/science.aar3247"},{"title":"Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention (DETECT-A)","journal":"Science","year":2020,"doi":"10.1126/science.abb9601"}]},"route":"/people/nickolas-papadopoulos/","neighbours":{"technology":[{"id":"liquid-biopsy","kind":"technology","name":"Liquid biopsy (ctDNA)","route":"/technologies/liquid-biopsy/"},{"id":"mced","kind":"technology","name":"Multi-cancer early detection (MCED)","route":"/technologies/mced/"}],"institution":[{"id":"johns-hopkins","kind":"institution","name":"Johns Hopkins Hospital / Sidney Kimmel Comprehensive Cancer Center","route":"/institutions/johns-hopkins/"}],"paper":[{"id":"paper-cohen-ctdna-protein-liquid-biopsy-pancreatic-pnas-2017","kind":"paper","name":"Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers","route":"/key-papers/paper-cohen-ctdna-protein-liquid-biopsy-pancreatic-pnas-2017/"},{"id":"paper-jones-pancreatic-core-pathways-science-2008","kind":"paper","name":"Core signaling pathways in human pancreatic cancers revealed by global genomic analyses","route":"/key-papers/paper-jones-pancreatic-core-pathways-science-2008/"},{"id":"paper-detect-a-science-2020","kind":"paper","name":"DETECT-A: a blood test plus PET-CT found treatable cancers in 10,000 women with no symptoms","route":"/key-papers/paper-detect-a-science-2020/"},{"id":"paper-cohen-cancerseek-multi-analyte-blood-test-science-2018","kind":"paper","name":"Detection and localization of surgically resectable cancers with a multi-analyte blood test","route":"/key-papers/paper-cohen-cancerseek-multi-analyte-blood-test-science-2018/"}],"term":[{"id":"detect-a-study","kind":"term","name":"DETECT-A: a blood test plus PET-CT to screen 10,006 women with no symptoms","route":"/terms/detect-a-study/"}],"roadmap":[{"id":"ctdna-tests","kind":"roadmap","name":"ctDNA tests roadmap: from a curiosity in plasma to blood tests that decide treatment","route":"/roadmaps/ctdna-tests/"}]}}