{"entity":{"id":"nfkbia","kind":"target","name":"NFKBIA","aka":["NFKB inhibitor alpha","NF-kappa-B inhibitor alpha","MAD-3","IkappaBalpha","NFKBI"],"tldr":"NFKBIA (NF-kappa-B inhibitor alpha) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Multiple myeloma and Diffuse large B-cell lymphoma.","summary":"Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localisation signals. On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant. IntOGen calls it a driver in 5 cohorts (0 activating, 5 loss-of-function), covering Diffuse Large B-Cell Lymphoma, NOS, Malignant Lymphoma, Non-Hodgkin Lymphoma, Plasma Cell Myeloma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7797","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7797"},{"label":"UniProt P25963","url":"https://www.uniprot.org/uniprotkb/P25963/entry"},{"label":"NCBI Gene 4792","url":"https://www.ncbi.nlm.nih.gov/gene/4792"},{"label":"Ensembl ENSG00000100906","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000100906"}],"tags":["cancer-genes-wave"],"related":["civic","intogen"],"cancers":["non-hodgkin-lymphoma","multiple-myeloma","dlbcl"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 5 cohorts; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"NFKBIA","role":["tumour-suppressor","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:7797","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7797","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P25963","url":"https://www.uniprot.org/uniprotkb/P25963/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene NFKBIA","url":"https://civicdb.org/features/3885","note":"1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)"},{"label":"IntOGen NFKBIA","url":"https://www.intogen.org/search?gene=NFKBIA","note":"driver in 5 cohorts (Act 0, LoF 5); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"specificity":"tumour-specific","distribution":"few-types","specificityNote":"Tumour-specific alteration: the catalogues call it a tumour suppressor (IntOGen finds it knocked out more often than chance); what a medicine would aim at or exploit is the altered form or its loss, absent from normal cells; no corpus medicine is aimed at it yet. HPA NFKBIA: RNA tissue enhanced (bone marrow 961 nTPM); no normal tissue stained high; highest cancer staining prostate cancer (1 of 8 high). Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Lymphoma, Multiple myeloma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 6 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"UniProt P25963","url":"https://www.uniprot.org/uniprotkb/P25963/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene NFKBIA","url":"https://civicdb.org/features/3885","note":"1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)"},{"label":"IntOGen NFKBIA","url":"https://www.intogen.org/search?gene=NFKBIA","note":"driver in 5 cohorts (Act 0, LoF 5); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"},{"label":"Human Protein Atlas NFKBIA tissue","url":"https://www.proteinatlas.org/ENSG00000100906-NFKBIA/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000100906 associations","url":"https://platform.opentargets.org/target/ENSG00000100906/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:7797","ensembl":"ENSG00000100906","uniprot":"P25963","entrez":"4792","firstDescribed":1991,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Haskill et al, Cell, 1991, \"Characterization of an immediate-early gene induced in adherent monocytes that encodes I kappa B-like activity\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/1829648/","biology":"Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localisation signals. On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. Location: Cytoplasm; Nucleus (UniProt). Locus 14q13.2 (HGNC).","whereFound":["Non-Hodgkin lymphoma: IntOGen driver in 2 cohorts (MLYM, NHL)","Multiple myeloma: IntOGen driver in 1 cohort (PCM)","Diffuse large B-cell lymphoma: CIViC evidence names this disease; IntOGen driver in 2 cohorts (DLBCLNOS)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/nfkbia/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"},{"id":"multiple-myeloma","kind":"cancer","name":"Multiple myeloma","route":"/cancers/multiple-myeloma/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"}]}}