{"entity":{"id":"nct07673887","kind":"trial","name":"A Study of ASP2138 Together With Chemotherapy and Pembrolizumab in Adults With Gastric Cancer","aka":[],"tldr":"A phase 3 trial testing ASP2138 in gastric & gastro-oesophageal junction cancer, now recruiting.","summary":"A Study of ASP2138 Together With Chemotherapy and Pembrolizumab in Adults With Gastric Cancer is a phase 3 interventional study registered as NCT07673887, led by Astellas Pharma Global Development, and recruiting on the registry. Official title: A Phase 3, Global, Multi-centre, Double-blind, Randomised Study of ASP2138 Plus Chemotherapy (CAPOX or mFOLFOX6) With Pembrolizumab vs Placebo Plus Chemotherapy With or Without Pembrolizumab in First-line Treatment of Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma in Participants Whose Tumours Are HER2-negative and Claudin (CLDN) 18.2-positive. Planned enrolment is 570 participants (estimated). The study started in 2026-06-30 and primary completion is expected in 2031-02-28. No results have been posted on ClinicalTrials.gov.","status":"recruiting","asOf":"2026-09-11","links":[{"label":"ClinicalTrials.gov NCT07673887","url":"https://clinicaltrials.gov/study/NCT07673887"}],"tags":["ctgov-ingest"],"related":[],"cancers":["gastric"],"sections":[],"technologies":[],"targets":[],"drugs":["asp2138"],"companies":["astellas"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07673887","phase":"3","setting":"A Phase 3, Global, Multi-center, Double-blind, Randomized Study of ASP2138 Plus Chemotherapy (CAPOX or mFOLFOX6) With Pembrolizumab vs Placebo Plus Chemotherapy With or Without Pembrolizumab in First-line Treatment of Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma in Participants Whose Tumors Are HER2-negative and Claudin (CLDN) 18.2-positive","sponsor":"Astellas Pharma Global Development","started":"2026-06-30","startedType":"actual","enrolled":570,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07673887/","neighbours":{"cancer":[{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"}],"drug":[{"id":"asp2138","kind":"drug","name":"ASP2138","route":"/drugs/asp2138/"}],"company":[{"id":"astellas","kind":"company","name":"Astellas","route":"/companies/astellas/"}]}}