{"entity":{"id":"nct07218926","kind":"trial","name":"A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastrointestinal Stromal Tumors After Imatinib Therapy","aka":["StrateGIST 3"],"tldr":"A phase 3 trial testing IDRX-42 in gastrointestinal stromal tumour, now recruiting.","summary":"A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastrointestinal Stromal Tumours After Imatinib Therapy is a phase 3 interventional study registered as NCT07218926, led by GlaxoSmithKline, and recruiting on the registry. Official title: A Phase 3, Randomised, Multicenter, Open-Label Study of IDRX-42 (GSK6042981) Versus Sunitinib in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumours (GIST) After Imatinib Therapy (StrateGIST 3). Planned enrolment is 450 participants (estimated). The study started in 2025-12-03 and primary completion is expected in 2028-05-30. No results have been posted on ClinicalTrials.gov.","status":"recruiting","asOf":"2026-09-11","links":[{"label":"ClinicalTrials.gov NCT07218926","url":"https://clinicaltrials.gov/study/NCT07218926"}],"tags":["ctgov-ingest"],"related":[],"cancers":["gist","gist-imatinib-resistant"],"sections":[],"technologies":[],"targets":[],"drugs":["idrx-42"],"companies":["gsk"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07218926","phase":"3","setting":"A Phase 3, Randomized, Multicenter, Open-Label Study of IDRX-42 (GSK6042981) Versus Sunitinib in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumors (GIST) After Imatinib Therapy (StrateGIST 3)","sponsor":"GlaxoSmithKline","started":"2025-12-03","startedType":"actual","enrolled":450,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07218926/","neighbours":{"cancer":[{"id":"gist","kind":"cancer","name":"Gastrointestinal stromal tumour (GIST)","route":"/cancers/gist/"},{"id":"gist-imatinib-resistant","kind":"cancer","name":"Imatinib-resistant GIST","route":"/cancers/gist-imatinib-resistant/"}],"drug":[{"id":"idrx-42","kind":"drug","name":"IDRX-42","route":"/drugs/idrx-42/"}],"company":[{"id":"gsk","kind":"company","name":"GSK","route":"/companies/gsk/"}]}}