{"entity":{"id":"nct07188558","kind":"trial","name":"A Study to Investigate Ronde-cel Versus Investigator's Choice CD19 CAR T-Cell Therapy","aka":["PiNACLE-H2H"],"tldr":"A phase 3 trial testing Rondecabtagene autoleucel in diffuse large B-cell lymphoma and hodgkin lymphoma, now recruiting.","summary":"A Study to Investigate Ronde-cel Versus Investigator's Choice CD19 CAR T-Cell Therapy is a phase 3 interventional study registered as NCT07188558, led by Lyell Immunopharma, and recruiting on the registry. Official title: A Phase 3 Randomised Controlled Trial of Rondecabtagene Autoleucel, an Autologous, Dual-targeting CD19/CD20 CAR T-Cell Product Candidate, Vs. Investigator's Choice of CD19 CAR T-Cell Therapy in Patients With Relapsed or Refractory Large B-Cell Lymphoma in the Second-line Setting. Planned enrolment is 400 participants (estimated). The study started in 2026-01-12 and primary completion is expected in 2029-12. No results have been posted on ClinicalTrials.gov.","status":"recruiting","asOf":"2026-09-11","links":[{"label":"ClinicalTrials.gov NCT07188558","url":"https://clinicaltrials.gov/study/NCT07188558"}],"tags":["ctgov-ingest"],"related":[],"cancers":["dlbcl","hodgkin-lymphoma"],"sections":[],"technologies":[],"targets":[],"drugs":["rondecabtagene-autoleucel"],"companies":["lyell-immunopharma"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07188558","phase":"3","setting":"A Phase 3 Randomized Controlled Trial of Rondecabtagene Autoleucel, an Autologous, Dual-targeting CD19/CD20 CAR T-Cell Product Candidate, Vs. Investigator's Choice of CD19 CAR T-Cell Therapy in Patients With Relapsed or Refractory Large B-Cell Lymphoma in the Second-line Setting","sponsor":"Lyell Immunopharma","started":"2026-01-12","startedType":"actual","enrolled":400,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07188558/","neighbours":{"cancer":[{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"},{"id":"hodgkin-lymphoma","kind":"cancer","name":"Hodgkin lymphoma","route":"/cancers/hodgkin-lymphoma/"}],"drug":[{"id":"rondecabtagene-autoleucel","kind":"drug","name":"Rondecabtagene autoleucel","route":"/drugs/rondecabtagene-autoleucel/"}],"company":[{"id":"lyell-immunopharma","kind":"company","name":"Lyell Immunopharma","route":"/companies/lyell-immunopharma/"}]}}