{"entity":{"id":"nct06295731","kind":"trial","name":"INBRX-106 in Combination With Pembrolizumab in First-line PD-L1 CPS≥20 HNSCC","aka":["HexAgon-HN"],"tldr":"A phase 2/3 trial testing INBRX-106 in head and neck squamous cell carcinoma, active and no longer recruiting.","summary":"INBRX-106 in Combination With Pembrolizumab in First-line PD-L1 CPS≥20 HNSCC is a phase 2/3 interventional study registered as NCT06295731, led by Inhibrx Biosciences, and active but no longer recruiting on the registry. Official title: A Phase 2/3, Randomised Study of INBRX-106 Combined With Pembrolizumab Versus Pembrolizumab as First Line Treatment for Patients With Recurrent or Metastatic (R/M) Head and Neck Squamous Cell Carcinoma (HNSCC) Expressing PD-L1 (CPS ≥20) (HexAgon-HN). Planned enrolment is 410 participants (estimated). The study started in 2024-05-14 and primary completion is expected in 2029-05. No results have been posted on ClinicalTrials.gov.","status":"active","asOf":"2026-09-11","links":[{"label":"ClinicalTrials.gov NCT06295731","url":"https://clinicaltrials.gov/study/NCT06295731"}],"tags":["ctgov-ingest"],"related":[],"cancers":["head-and-neck","recurrent-metastatic-hnscc"],"sections":[],"technologies":[],"targets":[],"drugs":["inbrx-106"],"companies":["inhibrx"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06295731","phase":"2/3","setting":"A Phase 2/3, Randomized Study of INBRX-106 Combined With Pembrolizumab Versus Pembrolizumab as First Line Treatment for Patients With Recurrent or Metastatic (R/M) Head and Neck Squamous Cell Carcinoma (HNSCC) Expressing PD-L1 (CPS ≥20) (HexAgon-HN)","sponsor":"Inhibrx Biosciences","started":"2024-05-14","startedType":"actual","enrolled":410,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06295731/","neighbours":{"cancer":[{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"recurrent-metastatic-hnscc","kind":"cancer","name":"Recurrent or metastatic head and neck squamous cell carcinoma","route":"/cancers/recurrent-metastatic-hnscc/"}],"drug":[{"id":"inbrx-106","kind":"drug","name":"INBRX-106","route":"/drugs/inbrx-106/"}],"company":[{"id":"inhibrx","kind":"company","name":"Inhibrx Biosciences","route":"/companies/inhibrx/"}]}}