{"entity":{"id":"nct05876754","kind":"trial","name":"An Early Access Study of Ivosidenib in Patients With a Pretreated Locally Advanced or Metastatic Cholangiocarcinoma","aka":["ProvIDHe"],"tldr":"A phase 3 trial of Ivosidenib in biliary tract cancer, run by Servier Affaires Médicales, active and no longer recruiting.","summary":"An Early Access Study of Ivosidenib in Patients With a Pretreated Locally Advanced or Metastatic Cholangiocarcinoma is a phase 3 interventional study registered as NCT05876754 by Servier Affaires Médicales, with 299 participants enrolled, started 2023-05-03 and due to reach its primary completion in 2027-12-01. Interventions recorded: Ivosidenib Oral Tablet.","status":"active","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT05876754","url":"https://clinicaltrials.gov/study/NCT05876754"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["cholangiocarcinoma"],"sections":[],"technologies":["epigenetic-drugs","idh-inhibitors","kinase-inhibitors"],"targets":[],"drugs":["ivosidenib"],"companies":["servier"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05876754","phase":"3","setting":"An Open-Label Early Access Phase 3b Study of Ivosidenib in Patients With a Pretreated Locally Advanced or Metastatic Cholangiocarcinoma","sponsor":"Servier Affaires Médicales","started":"2023-05-03","startedType":"actual","enrolled":299,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05876754/","neighbours":{"cancer":[{"id":"cholangiocarcinoma","kind":"cancer","name":"Biliary tract cancer (cholangiocarcinoma)","route":"/cancers/cholangiocarcinoma/"}],"technology":[{"id":"epigenetic-drugs","kind":"technology","name":"Epigenetic drugs (HDAC, DNMT, EZH2, IDH, menin, BET)","route":"/technologies/epigenetic-drugs/"},{"id":"idh-inhibitors","kind":"technology","name":"IDH inhibitors","route":"/technologies/idh-inhibitors/"},{"id":"kinase-inhibitors","kind":"technology","name":"Small-molecule kinase inhibitors","route":"/technologies/kinase-inhibitors/"}],"drug":[{"id":"ivosidenib","kind":"drug","name":"Ivosidenib","route":"/drugs/ivosidenib/"}],"company":[{"id":"servier","kind":"company","name":"Servier","route":"/companies/servier/"}]}}