{"entity":{"id":"nct05744687","kind":"trial","name":"Phase II/III Study of SPH4336 Combined With Letrozole vs Placebo Combined With Letrozole in First-line Treatment of Breast Cancer","aka":[],"tldr":"A phase 2/3 trial testing SPH4336 in HR-positive / HER2-negative breast cancer, now recruiting.","summary":"Phase II/III Study of SPH4336 Combined With Letrozole vs Placebo Combined With Letrozole in First-line Treatment of Breast Cancer is a phase 2/3 interventional study registered as NCT05744687, led by Shanghai Pharmaceuticals, and recruiting on the registry. Official title: Randomised, Double-blind, Placebo-controlled, Phase II/III Study of SPH4336 Combined With Letrozole vs Placebo Combined With Letrozole in First-line Treatment of HR-positive, HER2-negative Locally Advanced or Metastatic Breast Cancer. Planned enrolment is 374 participants (estimated). The study started in 2023-04-24 and primary completion is expected in 2026-05-31. No results have been posted on ClinicalTrials.gov.","status":"recruiting","asOf":"2026-09-11","links":[{"label":"ClinicalTrials.gov NCT05744687","url":"https://clinicaltrials.gov/study/NCT05744687"}],"tags":["ctgov-ingest"],"related":[],"cancers":["breast-hr-positive"],"sections":[],"technologies":[],"targets":[],"drugs":["sph4336"],"companies":["shanghai-pharmaceuticals"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05744687","phase":"2/3","setting":"Randomized, Double-blind, Placebo-controlled, Phase II/III Study of SPH4336 Combined With Letrozole vs Placebo Combined With Letrozole in First-line Treatment of HR-positive, HER2-negative Locally Advanced or Metastatic Breast Cancer","sponsor":"Shanghai Pharmaceuticals","started":"2023-04-24","startedType":"actual","enrolled":374,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05744687/","neighbours":{"cancer":[{"id":"breast-hr-positive","kind":"cancer","name":"HR-positive / HER2-negative breast cancer","route":"/cancers/breast-hr-positive/"}],"drug":[{"id":"sph4336","kind":"drug","name":"SPH4336","route":"/drugs/sph4336/"}],"company":[{"id":"shanghai-pharmaceuticals","kind":"company","name":"Shanghai Pharmaceuticals","route":"/companies/shanghai-pharmaceuticals/"}]}}