{"entity":{"id":"nct05320198","kind":"trial","name":"Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia","aka":["RALLY-MF"],"tldr":"A phase 1/2 trial of DISC-0974 in myeloproliferative neoplasms and myelodysplastic syndromes / neoplasms, run by Disc Medicine, Inc, now recruiting.","summary":"Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia is a phase 1/2 interventional study registered as NCT05320198 by Disc Medicine, Inc, with 150 participants planned, started 2022-06-06 and due to reach its primary completion in 2027-05. Interventions recorded: DISC-0974.","status":"recruiting","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT05320198","url":"https://clinicaltrials.gov/study/NCT05320198"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["myeloproliferative-neoplasms","mds","primary-myelofibrosis"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":["disc-medicine"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05320198","phase":"1/2","setting":"RALLY-MF: A Phase 1b/2 Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of DISC-0974 in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia","sponsor":"Disc Medicine, Inc","started":"2022-06-06","startedType":"actual","enrolled":150,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05320198/","neighbours":{"cancer":[{"id":"mds-lower-risk","kind":"cancer","name":"Lower-risk myelodysplastic syndromes","route":"/cancers/mds-lower-risk/"},{"id":"mds","kind":"cancer","name":"Myelodysplastic syndromes / neoplasms (MDS)","route":"/cancers/mds/"},{"id":"myeloproliferative-neoplasms","kind":"cancer","name":"Myeloproliferative neoplasms (PV, ET, myelofibrosis)","route":"/cancers/myeloproliferative-neoplasms/"},{"id":"primary-myelofibrosis","kind":"cancer","name":"Primary myelofibrosis","route":"/cancers/primary-myelofibrosis/"}],"company":[{"id":"disc-medicine","kind":"company","name":"Disc Medicine","route":"/companies/disc-medicine/"}]}}