{"entity":{"id":"nct05155254","kind":"trial","name":"IO102-IO103 in Combination With Pembrolizumab Versus Pembrolizumab Alone in Advanced Melanoma (IOB-013 / KN-D18)","aka":[],"tldr":"A phase 3 trial testing IO102-IO103 in melanoma, active and no longer recruiting.","summary":"IO102-IO103 in Combination With Pembrolizumab Versus Pembrolizumab Alone in Advanced Melanoma (IOB-013 / KN-D18) is a phase 3 interventional study registered as NCT05155254, led by IO Biotech with Syneos Health and Merck Sharp & Dohme, and active but no longer recruiting on the registry. Official title: An Open-label, Randomised, Phase 3 Clinical Trial of IO102-IO103 in Combination With Pembrolizumab Versus Pembrolizumab Alone in Patients With Previously Untreated, Unresectable, or Metastatic (Advanced) Melanoma (IO102-IO103-013 / MK3475-D18). Planned enrolment is 407 participants (actual). The study started in 2022-05-17 and primary completion is expected in 2025-05-30. No results have been posted on ClinicalTrials.gov.","status":"active","asOf":"2026-09-11","links":[{"label":"ClinicalTrials.gov NCT05155254","url":"https://clinicaltrials.gov/study/NCT05155254"}],"tags":["ctgov-ingest"],"related":[],"cancers":["melanoma","advanced-melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":["io102-io103"],"companies":["io-biotech"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05155254","phase":"3","setting":"An Open-label, Randomized, Phase 3 Clinical Trial of IO102-IO103 in Combination With Pembrolizumab Versus Pembrolizumab Alone in Patients With Previously Untreated, Unresectable, or Metastatic (Advanced) Melanoma (IO102-IO103-013 / MK3475-D18)","sponsor":"IO Biotech","started":"2022-05-17","startedType":"actual","enrolled":407,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05155254/","neighbours":{"cancer":[{"id":"advanced-melanoma","kind":"cancer","name":"Advanced melanoma (unresectable stage III and stage IV)","route":"/cancers/advanced-melanoma/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"}],"drug":[{"id":"io102-io103","kind":"drug","name":"IO102-IO103","route":"/drugs/io102-io103/"}],"company":[{"id":"io-biotech","kind":"company","name":"IO Biotech","route":"/companies/io-biotech/"}]}}