{"entity":{"id":"nct05141721","kind":"trial","name":"A Study of a Patient-Specific Neoantigen Vaccine in Combination With Immune Checkpoint Blockade for Patients With Metastatic Colorectal Cancer","aka":[],"tldr":"A phase 2/3 trial testing GRT-C901 in colorectal cancer, active and no longer recruiting.","summary":"A Study of a Patient-Specific Neoantigen Vaccine in Combination With Immune Checkpoint Blockade for Patients With Metastatic Colorectal Cancer is a phase 2/3 interventional study registered as NCT05141721, led by Seattle Project, and active but no longer recruiting on the registry. Official title: A Phase 2/3, Randomised, Open-Label Study of Maintenance GRT-C901/GRT-R902, A Neoantigen Vaccine, in Combination With Immune Checkpoint Blockade for Patients With Metastatic Colorectal Cancer. Planned enrolment is 700 participants (estimated). The study started in 2022-02-12 and primary completion is expected in 2027-03. No results have been posted on ClinicalTrials.gov.","status":"active","asOf":"2026-09-11","links":[{"label":"ClinicalTrials.gov NCT05141721","url":"https://clinicaltrials.gov/study/NCT05141721"}],"tags":["ctgov-ingest"],"related":[],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":["grt-c901","grt-r902"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05141721","phase":"2/3","setting":"A Phase 2/3, Randomized, Open-Label Study of Maintenance GRT-C901/GRT-R902, A Neoantigen Vaccine, in Combination With Immune Checkpoint Blockade for Patients With Metastatic Colorectal Cancer","sponsor":"Seattle Project","started":"2022-02-12","startedType":"actual","enrolled":700,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05141721/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}],"drug":[{"id":"grt-c901","kind":"drug","name":"GRT-C901","route":"/drugs/grt-c901/"},{"id":"grt-r902","kind":"drug","name":"GRT-R902","route":"/drugs/grt-r902/"}]}}