{"entity":{"id":"nct04353375","kind":"trial","name":"HMPL-453 Tartrate in Advanced Intrahepatic Cholangiocarcinoma","aka":[],"tldr":"A phase 2/3 trial testing HMPL-453 in biliary tract cancer, now recruiting.","summary":"HMPL-453 Tartrate in Advanced Intrahepatic Cholangiocarcinoma is a phase 2/3 interventional study registered as NCT04353375, led by Hutchmed, and recruiting on the registry. Official title: An Open-Label, Single-Arm, Multicenter Phase 2/3b Clinical Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of HMPL-453 Tartrate in Patients With Advanced Intrahepatic Cholangiocarcinoma Habouring FGFR2 Fusion/Rearrangement. Planned enrolment is 235 participants (estimated). The study started in 2020-09-03 and primary completion is expected in 2028-06-30. No results have been posted on ClinicalTrials.gov.","status":"recruiting","asOf":"2026-09-11","links":[{"label":"ClinicalTrials.gov NCT04353375","url":"https://clinicaltrials.gov/study/NCT04353375"}],"tags":["ctgov-ingest"],"related":[],"cancers":["cholangiocarcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":["hmpl-453"],"companies":["hutchmed"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT04353375","phase":"2/3","setting":"An Open-Label, Single-Arm, Multicenter Phase 2/3b Clinical Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of HMPL-453 Tartrate in Patients With Advanced Intrahepatic Cholangiocarcinoma Habouring FGFR2 Fusion/Rearrangement","sponsor":"Hutchmed","started":"2020-09-03","startedType":"actual","enrolled":235,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct04353375/","neighbours":{"cancer":[{"id":"cholangiocarcinoma","kind":"cancer","name":"Biliary tract cancer (cholangiocarcinoma)","route":"/cancers/cholangiocarcinoma/"}],"drug":[{"id":"hmpl-453","kind":"drug","name":"HMPL-453","route":"/drugs/hmpl-453/"}],"company":[{"id":"hutchmed","kind":"company","name":"Hutchmed","route":"/companies/hutchmed/"}]}}