{"entity":{"id":"natasha-leighl","kind":"person","name":"Natasha B. Leighl","aka":[],"tldr":"Lung cancer oncologist who showed plasma genotyping matches tissue and leads Canadian lung trials.","summary":"Natasha B. Leighl is Lung Site Lead in Medical Oncology and holds the OSI Pharmaceuticals Foundation Chair in Cancer New Drug Development at the Princess Margaret Cancer Centre. She is a lung cancer oncologist known for leading the NILE study, which showed that plasma cell-free DNA genotyping matches tissue testing in non-small-cell lung cancer, and for leading numerous Canadian Cancer Trials Group lung studies. Her selected paper reports the clinical utility of comprehensive cell-free DNA analysis in newly diagnosed metastatic lung cancer. A past president of the IASLC, she continues to work on liquid biopsy and health economics.","asOf":"2026-09-08","links":[{"label":"UHN profile","url":"https://www.uhnresearch.ca/researcher/natasha-b-leighl"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Leighl%20NB%5BAuthor%5D"}],"tags":[],"related":[],"cancers":["nsclc"],"sections":[],"technologies":["liquid-biopsy"],"targets":[],"drugs":[],"companies":[],"institutions":["princess-margaret"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Lung Site Lead, Medical Oncology; OSI Pharmaceuticals Foundation Chair in Cancer New Drug Development","institutionId":"princess-margaret","specialisms":["Lung cancer","Liquid biopsy","Health economics"],"profiles":[{"label":"UHN profile","url":"https://www.uhnresearch.ca/researcher/natasha-b-leighl"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Leighl%20NB%5BAuthor%5D"}],"papers":[{"title":"Clinical utility of comprehensive cell-free DNA analysis to identify genomic biomarkers in patients with newly diagnosed metastatic non-small cell lung cancer","journal":"Clinical Cancer Research","year":2019,"url":"https://doi.org/10.1158/1078-0432.CCR-19-0624","doi":"10.1158/1078-0432.CCR-19-0624"}]},"route":"/people/natasha-leighl/","neighbours":{"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"technology":[{"id":"liquid-biopsy","kind":"technology","name":"Liquid biopsy (ctDNA)","route":"/technologies/liquid-biopsy/"}],"institution":[{"id":"princess-margaret","kind":"institution","name":"Princess Margaret Cancer Centre","route":"/institutions/princess-margaret/"}]}}