{"entity":{"id":"naprt","kind":"target","name":"NAPRT","aka":["nicotinate phosphoribosyltransferase","Nicotinate phosphoribosyltransferase","PP3856","NAPRT1"],"tldr":"NAPRT (Nicotinate phosphoribosyltransferase) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"Catalyses the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming GNE-617.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:30450","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30450"},{"label":"UniProt Q6XQN6","url":"https://www.uniprot.org/uniprotkb/Q6XQN6/entry"},{"label":"NCBI Gene 93100","url":"https://www.ncbi.nlm.nih.gov/gene/93100"},{"label":"Ensembl ENSG00000147813","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000147813"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"NAPRT","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:30450","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30450","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q6XQN6","url":"https://www.uniprot.org/uniprotkb/Q6XQN6/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene NAPRT","url":"https://civicdb.org/features/17016","note":"1 evidence items, 0 assertions, 1 variants; diseases: Cancer (GraphQL API, CC0)"}],"distribution":"not-established","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA NAPRT: RNA tissue enhanced (liver 103 nTPM); high antibody staining in 5 normal tissues; highest cancer staining ovarian cancer (3 of 11 high). Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas NAPRT tissue","url":"https://www.proteinatlas.org/ENSG00000147813-NAPRT/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000147813 associations","url":"https://platform.opentargets.org/target/ENSG00000147813/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:30450","ensembl":"ENSG00000147813","uniprot":"Q6XQN6","entrez":"93100","firstDescribed":2003,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Huang C.-H. et al, 2003, \"Identification of nicotinate phosphoribosyltransferase as a novel FHA-HIT interaction protein (FHIP)\".","firstDescribedSource":"https://www.uniprot.org/uniprotkb/Q6XQN6/entry","biology":"Catalyses the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis. Location: Cytoplasm, cytosol (UniProt). Locus 8q24.3 (HGNC).","whereFound":[],"targetClass":"enzyme","prevalence":[]},"route":"/targets/naprt/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}]}}