{"entity":{"id":"nakagama-hitoshi","kind":"person","name":"Hitoshi Nakagama","aka":[],"tldr":"Leads Japan's national cancer centre, the hub of the country's genomic medicine and early-phase trial programmes.","summary":"Hitoshi Nakagama is President of the National Cancer Center Japan, the hub of the country's genomic medicine and early-phase trial programmes. A molecular carcinogenesis researcher, he oversees the centre's hospitals in Tokyo and Kashiwa, its research institute, and national programmes such as SCRUM-Japan and cancer genomic medicine built on comprehensive genomic profiling. His publications include a study of how the tumour-suppressive microRNA miR-34a induces senescence-like growth arrest through the E2F pathway in colon cancer cells, and a review of fatty pancreas as a possible risk factor for pancreatic cancer. His interests span cancer research leadership, prevention and molecular carcinogenesis.","asOf":"2026-09-08","links":[{"label":"National Cancer Center Japan","url":"https://www.ncc.go.jp/en/"},{"label":"PubMed author search","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Nakagama%20H%5BAuthor%5D%20National%20Cancer%20Center"}],"tags":[],"related":[],"cancers":[],"sections":[],"technologies":["cgp"],"targets":[],"drugs":[],"companies":[],"institutions":["ncc-japan"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["cancer-science"],"dependsOn":[],"notes":[],"role":"President, National Cancer Center Japan","institutionId":"ncc-japan","specialisms":["Cancer research leadership","Cancer prevention","Molecular carcinogenesis"],"profiles":[{"label":"National Cancer Center Japan","url":"https://www.ncc.go.jp/en/"},{"label":"PubMed author search","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Nakagama%20H%5BAuthor%5D%20National%20Cancer%20Center"}],"papers":[{"title":"Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells","journal":"Proceedings of the National Academy of Sciences","year":2007,"doi":"10.1073/pnas.0707351104"},{"title":"Fatty pancreas: A possible risk factor for pancreatic cancer in animals and humans","journal":"Cancer Science","year":2018,"doi":"10.1111/cas.13766"}]},"route":"/people/nakagama-hitoshi/","neighbours":{"technology":[{"id":"cgp","kind":"technology","name":"Comprehensive genomic profiling","route":"/technologies/cgp/"}],"institution":[{"id":"ncc-japan","kind":"institution","name":"National Cancer Center Hospital","route":"/institutions/ncc-japan/"}],"journal":[{"id":"cancer-science","kind":"journal","name":"Cancer science","route":"/journals/cancer-science/"}]}}