{"entity":{"id":"murray-brunt","kind":"person","name":"A. Murray Brunt","aka":[],"tldr":"Led FAST-Forward, which cut breast radiotherapy from three weeks to one with no loss of effectiveness.","summary":"Murray Brunt (Keele University) was chief investigator of FAST-Forward, the UK trial of 4,000 women showing that 26 Gy in five fractions over one week is non-inferior to 40 Gy in 15 fractions for local recurrence and normal tissue effects after breast conservation, a result adopted rapidly during the COVID-19 pandemic and now standard in many countries. He also led the FAST trial of five-fraction schedules over five weeks.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Brunt%20AM%5BAuthor%5D%20FAST-Forward"}],"tags":["radiotherapy","breast","hypofractionation"],"related":[],"cancers":["breast-hr-positive"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Professor of Clinical Oncology, Keele University; Consultant, University Hospitals of North Midlands","specialisms":["Breast radiotherapy","Hypofractionation","Radiotherapy trials"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Brunt%20AM%5BAuthor%5D%20FAST-Forward"}],"papers":[{"title":"Hypofractionated breast radiotherapy for 1 week versus 3 weeks (FAST-Forward): 5-year efficacy and late normal tissue effects results from a multicentre, non-inferiority, randomised, phase 3 trial","journal":"Lancet","year":2020,"doi":"10.1016/S0140-6736(20)30932-6"},{"title":"Ten-year results of FAST: a randomized controlled trial of 5-fraction whole-breast radiotherapy for early breast cancer","journal":"JCO","year":2020,"doi":"10.1200/JCO.19.02750"}]},"route":"/people/murray-brunt/","neighbours":{"cancer":[{"id":"breast-hr-positive","kind":"cancer","name":"HR-positive / HER2-negative breast cancer","route":"/cancers/breast-hr-positive/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}]}}