{"entity":{"id":"mt-nd6","kind":"target","name":"MT-ND6","aka":["mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6","NADH-ubiquinone oxidoreductase chain 6","NAD6","ND6","MTND6"],"tldr":"MT-ND6 (NADH-ubiquinone oxidoreductase chain 6) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyses electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.\n\nOpen Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes clinical 0.67, literature 0.29, genetic association 0.63, somatic mutation 0.18, animal model 0.33).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7462","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7462"},{"label":"UniProt P03923","url":"https://www.uniprot.org/uniprotkb/P03923/entry"},{"label":"NCBI Gene 4541","url":"https://www.ncbi.nlm.nih.gov/gene/4541"},{"label":"Ensembl ENSG00000198695","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000198695"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.67. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MT-ND6","role":["drug-target"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:7462","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7462","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P03923","url":"https://www.uniprot.org/uniprotkb/P03923/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000198695","url":"https://platform.opentargets.org/target/ENSG00000198695/associations","note":"association with cancer (MONDO_0004992) 0.52;  (GraphQL API, CC0)"}],"distribution":"not-established","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA MT-ND6: RNA tissue enhanced (heart muscle 33,513 nTPM, skeletal muscle 54,271 nTPM); no normal tissue stained high. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas MT-ND6 tissue","url":"https://www.proteinatlas.org/ENSG00000198695-MT-ND6/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000198695 associations","url":"https://platform.opentargets.org/target/ENSG00000198695/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:7462","ensembl":"ENSG00000198695","uniprot":"P03923","entrez":"4541","firstDescribed":1981,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Anderson et al, Nature, 1981, \"Sequence and organization of the human mitochondrial genome\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/7219534/","biology":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyses electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I. Location: Mitochondrion inner membrane (UniProt). Locus mitochondria (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/mt-nd6/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}