{"entity":{"id":"monoclonal-antibody","kind":"technology","name":"Monoclonal antibodies","aka":[],"tldr":"Lab-made immune proteins that lock onto one target, either blocking it or flagging the cell for destruction.","summary":"Rituximab (1997) and trastuzumab (1998) founded the class. Mechanisms: signal blockade (trastuzumab, cetuximab), ligand sequestration (bevacizumab), effector recruitment (ADCC, CDC), and checkpoint blockade. The chassis for ADCs, bispecifics, and radio-conjugates. Subcutaneous and biosimilar versions expand access.","status":"standard-of-care","asOf":"2026-09-04","wikipedia":"https://en.wikipedia.org/wiki/Monoclonal_antibody_therapy","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Monoclonal_antibody_therapy"}],"tags":[],"related":["cd40-agonists","cd47-blockade"],"cancers":["non-hodgkin-lymphoma","dlbcl","follicular-lymphoma"],"sections":["targeted-therapy","immunotherapy"],"technologies":[],"targets":[],"drugs":[],"companies":["morphosys","alentis-therapeutics","bicara-therapeutics","bighat-biosciences","inhibrx","ose-immunotherapeutics","tradewind-bioscience","peregrine-avid"],"institutions":[],"pathways":[],"terms":["adcc","fc-effector","lymphoma-bio-lineage-antigen-cost"],"trials":["notable-trial"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":["monoclonal-antibody-manufacturing"],"notes":["Lymphoma: rituximab is the proof of the format and also the clearest illustration of its cost. CD20 is on every normal B cell, so the treatment empties the B-cell compartment, and what follows is low immunoglobulin, more infection, a blunted vaccine response and, specifically, hepatitis B reactivation, which is why surface antigen and core antibody are checked before the first dose. Because CD20 is not internalised, the antibody has to kill from outside, through complement and effector cells, so the format carries no payload."],"principle":"A humanised or fully human IgG binds a surface or soluble antigen; Fc engineering tunes effector function and half-life.","strengths":["High specificity","Long half-life","Platform for conjugates"],"limitations":["IV administration","Cannot reach intracellular targets"],"since":1997},"route":"/technologies/monoclonal-antibody/","neighbours":{"technology":[{"id":"monoclonal-antibody-manufacturing","kind":"technology","name":"Antibody manufacturing (CHO bioprocessing)","route":"/technologies/monoclonal-antibody-manufacturing/"},{"id":"adc","kind":"technology","name":"Antibody-drug conjugate (ADC)","route":"/technologies/adc/"},{"id":"biosimilar-manufacturing","kind":"technology","name":"Biosimilar manufacturing and 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