{"entity":{"id":"mn1","kind":"target","name":"MN1","aka":["MN1 proto-oncogene, transcriptional regulator","Transcriptional activator MN1","MGCR1-PEN","MGCR1"],"tldr":"MN1 (Transcriptional activator MN1) is a protein that switches other genes on and off. The public catalogues list it as a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Colorectal cancer, Skin cancer and 1 more.","summary":"Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL.\n\nCIViC holds 3 clinical evidence items and 2 assertions across 1 variant. Open Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes literature 0.95, animal model 0.45, genetic association 0.52, somatic mutation 0.82).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7180","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7180"},{"label":"UniProt Q10571","url":"https://www.uniprot.org/uniprotkb/Q10571/entry"},{"label":"NCBI Gene 4330","url":"https://www.ncbi.nlm.nih.gov/gene/4330"},{"label":"Ensembl ENSG00000169184","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000169184"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets"],"cancers":["breast-cancer","colorectal","skin-cancer","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 3 clinical evidence items on its variants; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Astroblastoma, MN1-altered."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MN1","role":["biomarker","fusion-partner"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:7180","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7180","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q10571","url":"https://www.uniprot.org/uniprotkb/Q10571/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene MN1","url":"https://civicdb.org/features/3564","note":"3 evidence items, 2 assertions, 1 variants; diseases: Astroblastoma, MN1-altered (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000169184","url":"https://platform.opentargets.org/target/ENSG00000169184/associations","note":"association with cancer (MONDO_0004992) 0.71; per-cancer scores at or above 0.5: colorectal cancer 0.52, melanoma 0.51, skin cancer 0.51, breast cancer 0.60 (GraphQL API, CC0)"}],"specificity":"tumour-specific","distribution":"few-types","specificityNote":"Tumour-specific alteration: the catalogues call it a fusion partner (UniProt records a translocation); what a medicine would aim at or exploit is the altered form or its loss, absent from normal cells; no corpus medicine is aimed at it yet. HPA MN1: RNA tissue enhanced (blood vessel 22 nTPM, skeletal muscle 47 nTPM); high antibody staining in 27 normal tissues; highest cancer staining skin cancer (8 of 12 high). Distribution: 3 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Breast cancer (all types), Colorectal cancer, Skin cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 6 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"UniProt Q10571","url":"https://www.uniprot.org/uniprotkb/Q10571/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene MN1","url":"https://civicdb.org/features/3564","note":"3 evidence items, 2 assertions, 1 variants; diseases: Astroblastoma, MN1-altered (GraphQL API, CC0)"},{"label":"Human Protein Atlas MN1 tissue","url":"https://www.proteinatlas.org/ENSG00000169184-MN1/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000169184 associations","url":"https://platform.opentargets.org/target/ENSG00000169184/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:7180","ensembl":"ENSG00000169184","uniprot":"Q10571","entrez":"4330","firstDescribed":1995,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Deprez R.H.L. et al, Oncogene, 1995, \"Cloning and characterization of MN1, a gene from chromosome 22q11, which is disrupted by a balanced translocation in a meningioma\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/7731706/","biology":"Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull. May play a role in tumour suppression. Location: Nucleus (UniProt). Locus 22q12.1 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.60 with breast cancer (MONDO_0007254)","Colorectal cancer: Open Targets association 0.52 with colorectal cancer (MONDO_0005575)","Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898)","Melanoma: Open Targets association 0.51 with melanoma (MONDO_0005105)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/mn1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}