{"entity":{"id":"mmp9","kind":"target","name":"MMP9","aka":["matrix metallopeptidase 9","Matrix metalloproteinase-9","CLG4B"],"tldr":"MMP9 (Matrix metalloproteinase-9) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Bevacizumab.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7176","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7176"},{"label":"UniProt P14780","url":"https://www.uniprot.org/uniprotkb/P14780/entry"},{"label":"NCBI Gene 4318","url":"https://www.ncbi.nlm.nih.gov/gene/4318"},{"label":"Ensembl ENSG00000100985","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000100985"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["pre-metastatic-niche"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Inflammatory Breast Carcinoma."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MMP9","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:7176","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7176","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P14780","url":"https://www.uniprot.org/uniprotkb/P14780/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene MMP9","url":"https://civicdb.org/features/3553","note":"1 evidence items, 0 assertions, 1 variants; diseases: Inflammatory Breast Carcinoma (GraphQL API, CC0)"}],"distribution":"not-established","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA group enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA MMP9: RNA group enriched (bone marrow 356 nTPM, lymphoid tissue 103 nTPM); blood lineage lineage enriched (granulocytes 273 nTPM); high antibody staining in 3 normal tissues. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas MMP9 tissue","url":"https://www.proteinatlas.org/ENSG00000100985-MMP9/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000100985 associations","url":"https://platform.opentargets.org/target/ENSG00000100985/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:7176","ensembl":"ENSG00000100985","uniprot":"P14780","entrez":"4318","firstDescribed":1989,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Wilhelm S.M. et al, J. Biol. Chem, 1989, \"SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/2551898/","biology":"Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves NINJ1 to generate the Secreted ninjurin-1 form. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide. Location: Secreted, extracellular space, extracellular matrix (UniProt). Locus 20q13.12 (HGNC).","whereFound":[],"targetClass":"enzyme","prevalence":[]},"route":"/targets/mmp9/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"pathway":[{"id":"pre-metastatic-niche","kind":"pathway","name":"The pre-metastatic niche","route":"/pathways/pre-metastatic-niche/"}]}}