{"entity":{"id":"mmp7","kind":"target","name":"MMP7","aka":["matrix metallopeptidase 7","Matrilysin","PUMP-1","MPSL1"],"tldr":"MMP7 (Matrilysin) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.\n\nOpen Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.99, animal model 0.26, genetic association 0.61, clinical 0.65).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7174","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7174"},{"label":"UniProt P09237","url":"https://www.uniprot.org/uniprotkb/P09237/entry"},{"label":"NCBI Gene 4316","url":"https://www.ncbi.nlm.nih.gov/gene/4316"},{"label":"Ensembl ENSG00000137673","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000137673"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.65. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MMP7","role":["drug-target"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:7174","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7174","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P09237","url":"https://www.uniprot.org/uniprotkb/P09237/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000137673","url":"https://platform.opentargets.org/target/ENSG00000137673/associations","note":"association with cancer (MONDO_0004992) 0.57;  (GraphQL API, CC0)"}],"distribution":"one-type","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA MMP7: RNA tissue enhanced (gallbladder 479 nTPM, salivary gland 253 nTPM, urinary bladder 197 nTPM); no normal tissue stained high; highest cancer staining endometrial cancer (2 of 12 high). Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 1 specific cancer type at or above 0.5 (prostate carcinoma). (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas MMP7 tissue","url":"https://www.proteinatlas.org/ENSG00000137673-MMP7/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000137673 associations","url":"https://platform.opentargets.org/target/ENSG00000137673/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:7174","ensembl":"ENSG00000137673","uniprot":"P09237","entrez":"4316","firstDescribed":1988,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Muller et al, Biochem. J, 1988, \"The collagenase gene family in humans consists of at least four members\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/2844164/","biology":"Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase. Location: Secreted, extracellular space, extracellular matrix (UniProt). Locus 11q22.2 (HGNC).","whereFound":[],"targetClass":"enzyme","prevalence":[]},"route":"/targets/mmp7/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}