{"entity":{"id":"mmp1","kind":"target","name":"MMP1","aka":["matrix metallopeptidase 1","Interstitial collagenase"],"tldr":"MMP1 (Interstitial collagenase) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to HR-positive / HER2-negative breast cancer.","summary":"Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Sacituzumab Govitecan.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7155","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7155"},{"label":"UniProt P03956","url":"https://www.uniprot.org/uniprotkb/P03956/entry"},{"label":"NCBI Gene 4312","url":"https://www.ncbi.nlm.nih.gov/gene/4312"},{"label":"Ensembl ENSG00000196611","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000196611"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["breast-hr-positive"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MMP1","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:7155","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7155","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P03956","url":"https://www.uniprot.org/uniprotkb/P03956/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene MMP1","url":"https://civicdb.org/features/3548","note":"1 evidence items, 0 assertions, 1 variants; diseases: Oestrogen Receptor-positive Breast Cancer (GraphQL API, CC0)"}],"distribution":"one-type","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA MMP1: RNA tissue enhanced (gallbladder 71 nTPM, stomach 1 44 nTPM, urinary bladder 49 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Breast cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas MMP1 tissue","url":"https://www.proteinatlas.org/ENSG00000196611-MMP1/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000196611 associations","url":"https://platform.opentargets.org/target/ENSG00000196611/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:7155","ensembl":"ENSG00000196611","uniprot":"P03956","entrez":"4312","firstDescribed":1986,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Whitham S.E. et al, Biochem. J, 1986, \"Comparison of human stromelysin and collagenase by cloning and sequence analysis\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/3030290/","biology":"Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity. Location: Secreted, extracellular space, extracellular matrix (UniProt). Locus 11q22.2 (HGNC).","whereFound":["HR-positive / HER2-negative breast cancer: CIViC evidence names this disease"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/mmp1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"breast-hr-positive","kind":"cancer","name":"HR-positive / HER2-negative breast cancer","route":"/cancers/breast-hr-positive/"}]}}