{"entity":{"id":"mmaf","kind":"term","name":"MMAF","aka":["monomethyl auristatin F","mafodotin payload","monomethyl auristatin F, mafodotin"],"tldr":"MMAF is a charged cousin of MMAE that cannot cross membranes, so it kills only the targeted cell and spares neighbours. Eye side effects are characteristic.","summary":"MMAF, monomethyl auristatin F, is a charged cousin of MMAE that cannot cross cell membranes, so it kills only the cell the antibody targets and spares its neighbours. The charge comes from a C-terminal phenylalanine, which stops the free payload leaving the cell. Used with non-cleavable linkers, in the form known as mafodotin, it produces little Bystander effect (ADC) and less neuropathy than MMAE, but it has a distinctive corneal toxicity seen with Belantamab mafodotin. The payload belongs to the Antibody-drug conjugate (ADC) technology and to the terms Payload (ADC) and Tubulin inhibitor payloads, and it is referenced by the linker term Maleimidocaproyl (mc), non-cleavable, which is its usual partner.","asOf":"2026-09-09","wikipedia":"https://en.wikipedia.org/wiki/Monomethyl_auristatin_F","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Monomethyl_auristatin_F"}],"tags":[],"related":["bystander-effect"],"cancers":[],"sections":[],"technologies":["adc"],"targets":[],"drugs":["belantamab-mafodotin"],"companies":[],"institutions":[],"pathways":[],"terms":["payload","tubulin-inhibitor-payloads"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"ADC chemistry"},"route":"/terms/mmaf/","neighbours":{"term":[{"id":"bystander-effect","kind":"term","name":"Bystander effect (ADC)","route":"/terms/bystander-effect/"},{"id":"mc-non-cleavable","kind":"term","name":"Maleimidocaproyl (mc), non-cleavable","route":"/terms/mc-non-cleavable/"},{"id":"payload","kind":"term","name":"Payload (ADC)","route":"/terms/payload/"},{"id":"tubulin-inhibitor-payloads","kind":"term","name":"Tubulin inhibitor payloads","route":"/terms/tubulin-inhibitor-payloads/"}],"technology":[{"id":"adc","kind":"technology","name":"Antibody-drug conjugate (ADC)","route":"/technologies/adc/"}],"drug":[{"id":"belantamab-mafodotin","kind":"drug","name":"Belantamab mafodotin","route":"/drugs/belantamab-mafodotin/"}]}}