{"entity":{"id":"miriam-merad","kind":"person","name":"Miriam Merad","aka":[],"tldr":"Mapped how macrophages and dendritic cells in tumours suppress immunity, opening new immunotherapy targets.","summary":"Miriam Merad is Director of the Marc and Jennifer Lipschultz Precision Immunology Institute and Chair of the Department of Immunology and Immunotherapy at The Mount Sinai Hospital and Tisch Cancer Institute. She is an immunologist known for mapping how macrophages and dendritic cells in tumours suppress immunity, defining tissue-resident macrophage biology and using single-cell atlases of lung tumours to identify myeloid programmes such as TREM2 that shape response to immunotherapy. Her selected paper reports the innate immune landscape in early lung adenocarcinoma by paired single-cell analyses. She is president of the American Association of Immunologists and continues single-cell work in lung and liver cancer.","asOf":"2026-09-08","links":[{"label":"Mount Sinai profile","url":"https://profiles.mountsinai.org/miriam-merad"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Merad%20M%5BAuthor%5D"}],"tags":[],"related":[],"cancers":["nsclc","hcc"],"sections":[],"technologies":["single-cell-spatial"],"targets":[],"drugs":[],"companies":[],"institutions":["mount-sinai"],"pathways":[],"terms":["cold-vs-hot"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Director, Marc and Jennifer Lipschultz Precision Immunology Institute; Chair, Department of Immunology and Immunotherapy","institutionId":"mount-sinai","specialisms":["Myeloid cells","Tumour-associated macrophages","Single-cell immunology"],"profiles":[{"label":"Mount Sinai profile","url":"https://profiles.mountsinai.org/miriam-merad"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Merad%20M%5BAuthor%5D"}],"papers":[{"title":"Innate immune landscape in early lung adenocarcinoma by paired single-cell analyses","journal":"Cell","year":2017,"url":"https://doi.org/10.1016/j.cell.2017.04.014","doi":"10.1016/j.cell.2017.04.014"}]},"route":"/people/miriam-merad/","neighbours":{"cancer":[{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"technology":[{"id":"single-cell-spatial","kind":"technology","name":"Single-cell & spatial profiling","route":"/technologies/single-cell-spatial/"}],"institution":[{"id":"mount-sinai","kind":"institution","name":"The Mount Sinai Hospital / Tisch Cancer Institute","route":"/institutions/mount-sinai/"}],"term":[{"id":"cold-vs-hot","kind":"term","name":"Hot vs cold tumours","route":"/terms/cold-vs-hot/"}]}}