{"entity":{"id":"michelle-monje","kind":"person","name":"Michelle Monje","aka":[],"tldr":"Founded cancer neuroscience and led the GD2 CAR-T trial that produced the first regressions of diffuse midline glioma.","summary":"Michelle Monje showed that neuronal activity drives glioma growth through neuroligin-3 and synaptic integration, founding the field of cancer neuroscience, and led the first-in-human trial of GD2-directed CAR T cells in H3K27M-mutant diffuse midline glioma that produced radiographic and clinical improvements in a disease with no effective therapy. She was awarded a MacArthur Fellowship and leads paediatric neuro-oncology research at Stanford.","asOf":"2026-09-10","wikipedia":"https://en.wikipedia.org/wiki/Michelle_Monje","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Monje%20M%5BAuthor%5D%20glioma%20GD2%20OR%20neuroligin"}],"tags":["paediatric","glioma","car-t","cancer-neuroscience"],"related":[],"cancers":[],"sections":[],"technologies":["car-t"],"targets":[],"drugs":[],"companies":[],"institutions":["stanford","hhmi"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Professor of Neurology and Neurological Sciences, Stanford University; HHMI Investigator","institutionId":"stanford","specialisms":["Paediatric high-grade glioma","Cancer neuroscience","GD2 CAR T cells","Diffuse midline glioma"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Monje%20M%5BAuthor%5D%20glioma%20GD2%20OR%20neuroligin"}],"papers":[{"title":"GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas","journal":"Nature","year":2022,"doi":"10.1038/s41586-022-04489-4"},{"title":"Neuronal activity promotes glioma growth through neuroligin-3 secretion","journal":"Cell","year":2015,"doi":"10.1016/j.cell.2015.04.012"},{"title":"Electrical and synaptic integration of glioma into neural circuits","journal":"Nature","year":2019,"doi":"10.1038/s41586-019-1563-y"}],"orcid":"0000-0002-3547-237X"},"route":"/people/michelle-monje/","neighbours":{"technology":[{"id":"car-t","kind":"technology","name":"CAR-T cell therapy","route":"/technologies/car-t/"}],"institution":[{"id":"hhmi","kind":"institution","name":"Howard Hughes Medical Institute","route":"/institutions/hhmi/"},{"id":"stanford","kind":"institution","name":"Stanford Health Care / Stanford Cancer Institute","route":"/institutions/stanford/"}]}}