{"entity":{"id":"michael-bretthauer","kind":"person","name":"Michael Bretthauer","aka":[],"tldr":"Led NordICC, the first randomised trial of screening colonoscopy, which found smaller benefits than many expected.","summary":"Michael Bretthauer (University of Oslo) was principal investigator of NordICC, the Nordic and Polish randomised trial of invitation to screening colonoscopy, whose 2022 result of an 18% reduction in colorectal cancer incidence and no significant mortality benefit in the intention-to-screen analysis reset expectations for colonoscopy screening. He leads the Clinical Effectiveness Research Group and works on screening quality and trial methodology.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Bretthauer%20M%5BAuthor%5D%20colonoscopy%20screening"}],"tags":["screening","colorectal","epidemiology"],"related":[],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["oslo-radium-hospital"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":["paper-nordicc-nejm-2022"],"journals":[],"dependsOn":[],"notes":[],"role":"Professor of Medicine, University of Oslo; Gastroenterologist, Oslo University Hospital","institutionId":"oslo-radium-hospital","specialisms":["Colorectal cancer screening","Colonoscopy trials","Screening epidemiology"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Bretthauer%20M%5BAuthor%5D%20colonoscopy%20screening"}],"papers":[{"title":"Effect of colonoscopy screening on risks of colorectal cancer and related death (NordICC)","journal":"NEJM","year":2022,"doi":"10.1056/NEJMoa2208375"},{"title":"Population-based colonoscopy screening for colorectal cancer: a randomized clinical trial","journal":"JAMA Internal Medicine","year":2016,"doi":"10.1001/jamainternmed.2016.0960"}],"orcid":"0000-0001-9653-6886"},"route":"/people/michael-bretthauer/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"early-onset-colorectal","kind":"cancer","name":"Early-onset colorectal cancer (under 50)","route":"/cancers/early-onset-colorectal/"}],"institution":[{"id":"oslo-radium-hospital","kind":"institution","name":"Oslo University Hospital, The Norwegian Radium Hospital","route":"/institutions/oslo-radium-hospital/"}],"paper":[{"id":"paper-nordicc-nejm-2022","kind":"paper","name":"NordICC: inviting people to a screening colonoscopy reduced bowel cancer, but less than expected","route":"/key-papers/paper-nordicc-nejm-2022/"}],"roadmap":[{"id":"colorectal-roadmap","kind":"roadmap","name":"Colorectal cancer roadmap: from the adenoma-carcinoma sequence and the first screening trials to total mesorectal excision, oxaliplatin, RAS testing, immunotherapy for mismatch repair-deficient disease, ctDNA-guided treatment and organ preservation","route":"/roadmaps/colorectal-roadmap/"}]}}