{"entity":{"id":"meletios-dimopoulos","kind":"person","name":"Meletios A. Dimopoulos","aka":[],"tldr":"Greek haematologist who led POLLUX and CANDOR, two of the pivotal daratumumab combination trials in relapsed myeloma.","summary":"Meletios Dimopoulos (University of Athens) was principal investigator of POLLUX, which established daratumumab plus lenalidomide-dexamethasone in relapsed myeloma, and CANDOR (daratumumab plus carfilzomib), and co-led APOLLO and the ELOQUENT trials. He has authored the IMWG guidelines on renal impairment in myeloma and led the international consensus on Waldenström macroglobulinaemia treatment.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Dimopoulos%20MA%5BAuthor%5D%20myeloma%20daratumumab"}],"tags":["myeloma","trialist","greece"],"related":[],"cancers":["multiple-myeloma","waldenstrom"],"sections":[],"technologies":["monoclonal-antibody"],"targets":["cd38"],"drugs":[],"companies":[],"institutions":["nkua-athens"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Professor of Hematology and Medical Oncology, National and Kapodistrian University of Athens","institutionId":"nkua-athens","specialisms":["Multiple myeloma","Waldenström macroglobulinaemia","Daratumumab and carfilzomib combinations","Renal impairment"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Dimopoulos%20MA%5BAuthor%5D%20myeloma%20daratumumab"}],"papers":[{"title":"Daratumumab, lenalidomide, and dexamethasone for multiple myeloma (POLLUX)","journal":"NEJM","year":2016,"doi":"10.1056/NEJMoa1607751"},{"title":"Carfilzomib, dexamethasone, and daratumumab versus carfilzomib and dexamethasone for patients with relapsed or refractory multiple myeloma (CANDOR)","journal":"Lancet","year":2020,"doi":"10.1016/S0140-6736(20)30734-0"},{"title":"AQUILA: daratumumab versus active monitoring in high-risk smouldering multiple myeloma","journal":"New England Journal of Medicine","year":2025,"url":"https://doi.org/10.1056/NEJMoa2409029","doi":"10.1056/NEJMoa2409029"}],"orcid":"0000-0001-8990-3254"},"route":"/people/meletios-dimopoulos/","neighbours":{"cancer":[{"id":"multiple-myeloma","kind":"cancer","name":"Multiple myeloma","route":"/cancers/multiple-myeloma/"},{"id":"waldenstrom","kind":"cancer","name":"Waldenström macroglobulinaemia","route":"/cancers/waldenstrom/"}],"technology":[{"id":"monoclonal-antibody","kind":"technology","name":"Monoclonal antibodies","route":"/technologies/monoclonal-antibody/"}],"target":[{"id":"cd38","kind":"target","name":"CD38","route":"/targets/cd38/"}],"institution":[{"id":"nkua-athens","kind":"institution","name":"National and Kapodistrian University of Athens, School of Medicine","route":"/institutions/nkua-athens/"}],"trial":[{"id":"aquila","kind":"trial","name":"AQUILA","route":"/trials/aquila/"}]}}