{"entity":{"id":"mecom","kind":"target","name":"MECOM","aka":["MDS1 and EVI1 complex locus","Histone-lysine N-methyltransferase MECOM","MDS1-EVI1","PRDM3","KMT8E","MDS1","EVI1"],"tldr":"MECOM (Histone-lysine N-methyltransferase MECOM) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Prostate cancer, Endometrial cancer and 5 more.","summary":"Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signalling.\n\nCIViC holds 5 clinical evidence items and 1 assertion across 3 variants. Open Targets scores its association with cancer at 0.75 (direct and indirect evidence; datatypes affected pathway 0.26, literature 0.99, genetic association 0.63, somatic mutation 0.80, animal model 0.50). IntOGen calls it a driver in 6 cohorts (3 activating, 3 loss-of-function), covering Invasive Breast Carcinoma, Melanoma, Prostate Adenocarcinoma, Endometrial Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3498","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3498"},{"label":"UniProt Q03112","url":"https://www.uniprot.org/uniprotkb/Q03112/entry"},{"label":"NCBI Gene 2122","url":"https://www.ncbi.nlm.nih.gov/gene/2122"},{"label":"Ensembl ENSG00000085276","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000085276"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["breast-cancer","prostate","endometrial","skin-cancer","lung-cancer","ovarian","melanoma","aml"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 3 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 3 cohorts; CIViC holds 5 clinical evidence items on its variants; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Acute Myeloid Leukaemia With MECOM Rearrangement."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MECOM","role":["oncogene-driver","tumour-suppressor","biomarker","fusion-partner"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:3498","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3498","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q03112","url":"https://www.uniprot.org/uniprotkb/Q03112/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene MECOM","url":"https://civicdb.org/features/1771","note":"5 evidence items, 1 assertions, 3 variants; diseases: Acute Myeloid Leukaemia With MECOM Rearrangement, Acute Myeloid Leukaemia (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000085276","url":"https://platform.opentargets.org/target/ENSG00000085276/associations","note":"association with cancer (MONDO_0004992) 0.75; per-cancer scores at or above 0.5: prostate cancer 0.54, ovarian cancer 0.51, melanoma 0.61, skin cancer 0.57, breast cancer 0.59, lung cancer 0.54 (GraphQL API, CC0)"},{"label":"IntOGen MECOM","url":"https://www.intogen.org/search?gene=MECOM","note":"driver in 6 cohorts (Act 3, LoF 3); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"specificity":"tumour-specific","distribution":"many-types","specificityNote":"Tumour-specific alteration: the catalogues call it an oncogene driver (IntOGen cohort analysis finds it activated more often than chance) and a tumour suppressor (IntOGen finds it knocked out more often than chance) and a fusion partner (UniProt records a translocation), so the direction differs between cohorts but the alteration is somatic either way; what a medicine would aim at or exploit is the altered form or its loss, absent from normal cells; no corpus medicine is aimed at it yet. HPA MECOM: RNA tissue enhanced (stomach 1 69 nTPM); high antibody staining in 42 normal tissues; highest cancer staining ovarian cancer (10 of 11 high). Distribution: 7 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Breast cancer (all types), Prostate cancer, Endometrial cancer, Skin cancer (all types), Lung cancer (all types), Ovarian cancer, Leukaemia); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 6 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"UniProt Q03112","url":"https://www.uniprot.org/uniprotkb/Q03112/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene MECOM","url":"https://civicdb.org/features/1771","note":"5 evidence items, 1 assertions, 3 variants; diseases: Acute Myeloid Leukaemia With MECOM Rearrangement, Acute Myeloid Leukaemia (GraphQL API, CC0)"},{"label":"IntOGen MECOM","url":"https://www.intogen.org/search?gene=MECOM","note":"driver in 6 cohorts (Act 3, LoF 3); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"},{"label":"Human Protein Atlas MECOM tissue","url":"https://www.proteinatlas.org/ENSG00000085276-MECOM/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000085276 associations","url":"https://platform.opentargets.org/target/ENSG00000085276/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:3498","ensembl":"ENSG00000085276","uniprot":"Q03112","entrez":"2122","firstDescribed":1990,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Morishita et al, Oncogene, 1990, \"Unique expression of the human Evi-1 gene in an endometrial carcinoma cell line: sequence of cDNAs and structure of alternatively spliced transcripts\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/2115646/","biology":"Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signalling. Involved in haematopoiesis. Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1). Probably catalyses the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyse histone H3 'Lys-9' trimethylation. Location: Nucleus; Nucleus speckle; Cytoplasm (UniProt). Locus 3q26.2 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.59 with breast cancer (MONDO_0007254); IntOGen driver in 1 cohort (BRCA)","Prostate cancer: Open Targets association 0.54 with prostate cancer (MONDO_0008315); IntOGen driver in 1 cohort (PRAD)","Endometrial cancer: IntOGen driver in 1 cohort (UCEC)","Skin cancer: Open Targets association 0.57 with skin cancer (MONDO_0002898)","Lung cancer: Open Targets association 0.54 with lung cancer (MONDO_0008903)","Ovarian cancer: Open Targets association 0.51 with ovarian cancer (MONDO_0008170)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/mecom/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"},{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}