{"entity":{"id":"mdc-berlin","kind":"institution","name":"Max Delbrück Center for Molecular Medicine","aka":["MDC","Max-Delbrück-Centrum","Max Delbrück Center"],"tldr":"Berlin's Helmholtz molecular medicine institute, whose cancer research spans T-cell receptor therapies, single-cell biology and systems medicine.","summary":"Founded in 1992 on the Berlin-Buch campus, the Max Delbrück Center is a Helmholtz Association institute that works closely with Charité through the Experimental and Clinical Research Center and the Berlin Institute of Health. Thomas Blankenstein's group developed T-cell receptor gene therapy approaches that led to the spin-out T-knife, and the Berlin Institute for Medical Systems Biology under Nikolaus Rajewsky is a centre for single-cell and spatial transcriptomics. Other groups study cancer genomics, oncogenic signalling, tumour immunology and MYC-driven lymphoma. The centre contributes to the DKTK and the German Human Cell Atlas efforts.","asOf":"2026-09-09","wikipedia":"https://en.wikipedia.org/wiki/Max_Delbr%C3%BCck_Center_for_Molecular_Medicine_in_the_Helmholtz_Association","links":[{"label":"Homepage","url":"https://www.mdc-berlin.de/en"},{"label":"BIMSB","url":"https://www.mdc-berlin.de/bimsb"}],"tags":[],"related":["cellxgene-hca"],"cancers":["dlbcl","melanoma","colorectal"],"sections":["cell-therapy","drug-discovery"],"technologies":["tcr-t","single-cell-spatial","crispr-screens","rna-seq"],"targets":[],"drugs":[],"companies":[],"institutions":["charite","dkfz"],"pathways":[],"terms":[],"trials":[],"people":["maike-sander","nikolaus-rajewsky"],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"city":"Berlin","country":"DE","lat":52.634,"lng":13.503,"institutionType":"research-institute","website":"https://www.mdc-berlin.de","programs":["TCR gene therapy","Berlin Institute for Medical Systems Biology","Cancer genomics and signalling","Systems medicine with Charité"]},"route":"/institutions/mdc-berlin/","neighbours":{"collection":[{"id":"cellxgene-hca","kind":"collection","name":"CZ CELLxGENE / Human Cell Atlas","route":"/collections/cellxgene-hca/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"}],"section":[{"id":"cell-therapy","kind":"section","name":"Cell Therapy","route":"/fronts/cell-therapy/"},{"id":"drug-discovery","kind":"section","name":"Drug Discovery Platforms","route":"/fronts/drug-discovery/"}],"technology":[{"id":"crispr-screens","kind":"technology","name":"CRISPR functional genomics","route":"/technologies/crispr-screens/"},{"id":"rna-seq","kind":"technology","name":"RNA sequencing & expression profiling","route":"/technologies/rna-seq/"},{"id":"single-cell-spatial","kind":"technology","name":"Single-cell & spatial profiling","route":"/technologies/single-cell-spatial/"},{"id":"tcr-t","kind":"technology","name":"TCR-T cell therapy","route":"/technologies/tcr-t/"}],"institution":[{"id":"charite","kind":"institution","name":"Charité Universitätsmedizin Berlin","route":"/institutions/charite/"},{"id":"dkfz","kind":"institution","name":"German Cancer Research Center (DKFZ)","route":"/institutions/dkfz/"}],"person":[{"id":"maike-sander","kind":"person","name":"Maike Sander","route":"/people/maike-sander/"},{"id":"nikolaus-rajewsky","kind":"person","name":"Nikolaus Rajewsky","route":"/people/nikolaus-rajewsky/"}]}}