{"entity":{"id":"mc-vc-pabc","kind":"term","name":"mc-Val-Cit-PABC","aka":["valine-citrulline linker","vc-MMAE","mc-VC-PABC"],"tldr":"The mc-Val-Cit-PABC linker is the workhorse of the vedotin ADCs: a valine-citrulline dipeptide cut by cathepsin B, releasing MMAE with a bystander effect.","summary":"Maleimidocaproyl-valine-citrulline-p-aminobenzylcarbamate links through cysteine thiols, is stable in human plasma, and is cleaved by cathepsins in the lysosome. In mice it is cleaved prematurely by a serum carboxylesterase, which complicated early preclinical testing. Neutropenia is partly attributed to premature release near neutrophil elastase.","asOf":"2026-09-09","wikipedia":"https://en.wikipedia.org/wiki/Brentuximab_vedotin","links":[{"label":"Monoclonal antibody auristatin (vc-MMAE) conjugates (Doronina et al., Nature Biotechnology 2003)","url":"https://doi.org/10.1038/nbt832"}],"tags":[],"related":["mmae","bystander-effect"],"cancers":[],"sections":[],"technologies":["adc"],"targets":[],"drugs":["enfortumab-vedotin","brentuximab-vedotin","tisotumab-vedotin","telisotuzumab-vedotin","disitamab-vedotin"],"companies":[],"institutions":[],"pathways":[],"terms":["linker"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":["paper-doronina-nat-biotechnol"],"journals":[],"dependsOn":[],"notes":[],"category":"ADC chemistry"},"route":"/terms/mc-vc-pabc/","neighbours":{"term":[{"id":"bystander-effect","kind":"term","name":"Bystander effect (ADC)","route":"/terms/bystander-effect/"},{"id":"linker","kind":"term","name":"Linker (ADC)","route":"/terms/linker/"},{"id":"mmae","kind":"term","name":"MMAE","route":"/terms/mmae/"}],"technology":[{"id":"adc","kind":"technology","name":"Antibody-drug conjugate (ADC)","route":"/technologies/adc/"}],"drug":[{"id":"brentuximab-vedotin","kind":"drug","name":"Brentuximab vedotin","route":"/drugs/brentuximab-vedotin/"},{"id":"disitamab-vedotin","kind":"drug","name":"Disitamab vedotin","route":"/drugs/disitamab-vedotin/"},{"id":"enfortumab-vedotin","kind":"drug","name":"Enfortumab vedotin","route":"/drugs/enfortumab-vedotin/"},{"id":"telisotuzumab-vedotin","kind":"drug","name":"Telisotuzumab vedotin","route":"/drugs/telisotuzumab-vedotin/"},{"id":"tisotumab-vedotin","kind":"drug","name":"Tisotumab vedotin","route":"/drugs/tisotumab-vedotin/"}],"paper":[{"id":"paper-doronina-nat-biotechnol","kind":"paper","name":"Development of potent monoclonal antibody auristatin conjugates for cancer therapy","route":"/key-papers/paper-doronina-nat-biotechnol/"}]}}