{"entity":{"id":"matthew-smith","kind":"person","name":"Matthew R. Smith","aka":[],"tldr":"Led ARASENS and SPARTAN, trials that established darolutamide triplet therapy and apalutamide for prostate cancer.","summary":"Matthew Smith was principal investigator of ARASENS, which showed darolutamide added to androgen deprivation and docetaxel improves survival in metastatic hormone-sensitive prostate cancer, and of SPARTAN, which established apalutamide for non-metastatic castration-resistant disease. He has led landmark studies of bone loss and denosumab in men on hormone therapy.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Smith%20MR%5BAuthor%5D%20darolutamide%20OR%20apalutamide"}],"tags":["prostate","trialist"],"related":[],"cancers":["prostate"],"sections":[],"technologies":["androgen-deprivation"],"targets":["androgen-receptor"],"drugs":[],"companies":[],"institutions":["mgh"],"pathways":[],"terms":[],"trials":["arasens"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Director, Genitourinary Malignancies Program, Massachusetts General Hospital Cancer Center","institutionId":"mgh","specialisms":["Prostate cancer","Androgen receptor inhibitors","Bone health","Non-metastatic castration-resistant disease"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Smith%20MR%5BAuthor%5D%20darolutamide%20OR%20apalutamide"}],"papers":[{"title":"Darolutamide and survival in metastatic, hormone-sensitive prostate cancer (ARASENS)","journal":"NEJM","year":2022,"doi":"10.1056/NEJMoa2119115"},{"title":"Apalutamide treatment and metastasis-free survival in prostate cancer (SPARTAN)","journal":"NEJM","year":2018,"doi":"10.1056/NEJMoa1715546"}]},"route":"/people/matthew-smith/","neighbours":{"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"technology":[{"id":"androgen-deprivation","kind":"technology","name":"Androgen deprivation & AR pathway inhibitors","route":"/technologies/androgen-deprivation/"}],"target":[{"id":"androgen-receptor","kind":"target","name":"Androgen receptor","route":"/targets/androgen-receptor/"}],"institution":[{"id":"mgh","kind":"institution","name":"Massachusetts General Hospital Cancer Center","route":"/institutions/mgh/"}],"trial":[{"id":"arasens","kind":"trial","name":"ARASENS","route":"/trials/arasens/"}]}}