{"entity":{"id":"masatoshi-kudo","kind":"person","name":"Masatoshi Kudo","aka":[],"tldr":"Japanese hepatologist who led REFLECT, the trial that made lenvatinib a first-line option for liver cancer.","summary":"Masatoshi Kudo (Kindai University, Osaka) was principal investigator of REFLECT, which showed lenvatinib is non-inferior to sorafenib in unresectable hepatocellular carcinoma and became the first new first-line option in a decade. He has published extensively on combining systemic therapy with transarterial chemoembolisation and edits the journal Liver Cancer. He continues to lead HCC trials across Asia.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Kudo%20M%5BAuthor%5D%20hepatocellular%20lenvatinib"}],"tags":["hcc","japan","trialist"],"related":[],"cancers":["hcc"],"sections":[],"technologies":["kinase-inhibitors"],"targets":[],"drugs":[],"companies":[],"institutions":["kindai-university-hospital"],"pathways":[],"terms":[],"trials":["reflect"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Professor and Chairman, Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine","institutionId":"kindai-university-hospital","specialisms":["Hepatocellular carcinoma","Lenvatinib","Locoregional therapy","Hepatology"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Kudo%20M%5BAuthor%5D%20hepatocellular%20lenvatinib"}],"papers":[{"title":"Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial (REFLECT)","journal":"Lancet","year":2018,"doi":"10.1016/S0140-6736(18)30207-1"},{"title":"Lenvatinib plus transarterial chemoembolization for unresectable hepatocellular carcinoma (LAUNCH)","journal":"JCO","year":2023}],"orcid":"0000-0002-4102-3474"},"route":"/people/masatoshi-kudo/","neighbours":{"cancer":[{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"}],"technology":[{"id":"kinase-inhibitors","kind":"technology","name":"Small-molecule kinase inhibitors","route":"/technologies/kinase-inhibitors/"}],"institution":[{"id":"kindai-university-hospital","kind":"institution","name":"Kindai University Faculty of Medicine and Hospital","route":"/institutions/kindai-university-hospital/"}],"trial":[{"id":"reflect","kind":"trial","name":"REFLECT","route":"/trials/reflect/"}]}}