{"entity":{"id":"maria-victoria-mateos","kind":"person","name":"María-Victoria Mateos","aka":[],"tldr":"Led ALCYONE and the smouldering myeloma trials that showed treating early can delay progression to active disease.","summary":"María-Victoria Mateos (Salamanca) was principal investigator of ALCYONE, which established daratumumab with bortezomib-melphalan-prednisone in transplant-ineligible myeloma, and of the Spanish QuiRedex and the international AQUILA trials showing that treating high-risk smouldering myeloma with lenalidomide-dexamethasone or daratumumab delays progression and improves survival. She leads the Spanish Myeloma Group and IMWG guideline work.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Mateos%20MV%5BAuthor%5D%20myeloma"}],"tags":["myeloma","smouldering","spain"],"related":[],"cancers":["multiple-myeloma"],"sections":[],"technologies":["monoclonal-antibody"],"targets":["cd38"],"drugs":[],"companies":[],"institutions":["hospital-universitario-salamanca"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Consultant Hematologist and Director of the Myeloma Program, University Hospital of Salamanca","institutionId":"hospital-universitario-salamanca","specialisms":["Multiple myeloma","Smouldering myeloma","Daratumumab combinations","Early intervention"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Mateos%20MV%5BAuthor%5D%20myeloma"}],"papers":[{"title":"Daratumumab plus bortezomib, melphalan, and prednisone for untreated myeloma (ALCYONE)","journal":"NEJM","year":2018,"doi":"10.1056/NEJMoa1714678"},{"title":"Lenalidomide plus dexamethasone for high-risk smoldering multiple myeloma","journal":"NEJM","year":2013,"doi":"10.1056/NEJMoa1300439"}]},"route":"/people/maria-victoria-mateos/","neighbours":{"cancer":[{"id":"multiple-myeloma","kind":"cancer","name":"Multiple myeloma","route":"/cancers/multiple-myeloma/"}],"technology":[{"id":"monoclonal-antibody","kind":"technology","name":"Monoclonal antibodies","route":"/technologies/monoclonal-antibody/"}],"target":[{"id":"cd38","kind":"target","name":"CD38","route":"/targets/cd38/"}],"institution":[{"id":"hospital-universitario-salamanca","kind":"institution","name":"University Hospital of Salamanca / IBSAL","route":"/institutions/hospital-universitario-salamanca/"}]}}