{"entity":{"id":"marcela-maus","kind":"person","name":"Marcela V. Maus","aka":[],"tldr":"Cell therapy engineer whose CAR-TEAM cells produced rapid regressions of recurrent glioblastoma.","summary":"Marcela Maus leads a laboratory that engineers CAR T cells to overcome the barriers of solid tumours, including the CARv3-TEAM-E cells that secrete a T-cell-engaging antibody against EGFR and produced dramatic, if transient, radiographic regressions in recurrent glioblastoma in a 2024 first-in-human trial. She previously led the first EGFRvIII CAR-T trial at Penn and directs cellular immunotherapy at MGH.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Maus%20MV%5BAuthor%5D%20CAR%20T%20glioblastoma"}],"tags":["cell-therapy","car-t","solid-tumours"],"related":[],"cancers":["glioblastoma"],"sections":[],"technologies":["car-t","armored-car"],"targets":["egfr"],"drugs":[],"companies":[],"institutions":["mgh"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["science-translational-medicine"],"dependsOn":[],"notes":[],"role":"Director, Cellular Immunotherapy Program, Massachusetts General Hospital Cancer Center; Professor, Harvard Medical School","institutionId":"mgh","specialisms":["CAR T-cell therapy","Solid tumour cell therapy","Glioblastoma","CAR engineering"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Maus%20MV%5BAuthor%5D%20CAR%20T%20glioblastoma"}],"papers":[{"title":"Intraventricular CARv3-TEAM-E T cells in recurrent glioblastoma","journal":"NEJM","year":2024,"doi":"10.1056/NEJMoa2314390"},{"title":"A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma","journal":"Science Translational Medicine","year":2017,"doi":"10.1126/scitranslmed.aaa0984"}]},"route":"/people/marcela-maus/","neighbours":{"cancer":[{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"}],"technology":[{"id":"armored-car","kind":"technology","name":"Armoured, logic-gated & next-gen CARs","route":"/technologies/armored-car/"},{"id":"car-t","kind":"technology","name":"CAR-T cell therapy","route":"/technologies/car-t/"}],"target":[{"id":"egfr","kind":"target","name":"EGFR","route":"/targets/egfr/"}],"institution":[{"id":"mgh","kind":"institution","name":"Massachusetts General Hospital Cancer Center","route":"/institutions/mgh/"}],"journal":[{"id":"science-translational-medicine","kind":"journal","name":"Science Translational Medicine","route":"/journals/science-translational-medicine/"}]}}