{"entity":{"id":"marc-besselink","kind":"person","name":"Marc G. Besselink","aka":[],"tldr":"Dutch surgeon who leads the PREOPANC trials testing chemotherapy or chemoradiation before pancreatic cancer surgery.","summary":"Marc Besselink (Amsterdam UMC) leads the Dutch Pancreatic Cancer Group and was senior investigator of PREOPANC, the randomised trial showing neoadjuvant chemoradiotherapy improves long-term survival in resectable and borderline resectable pancreatic cancer, and of PREOPANC-2 comparing neoadjuvant FOLFIRINOX. He has led the DIPLOMA and LEOPARD trials of minimally invasive pancreatic surgery.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Besselink%20MG%5BAuthor%5D%20pancreatic%20PREOPANC"}],"tags":["pancreatic","surgery","neoadjuvant"],"related":[],"cancers":["pancreatic"],"sections":[],"technologies":["robotic-surgery"],"targets":[],"drugs":[],"companies":[],"institutions":["amsterdam-umc"],"pathways":[],"terms":[],"trials":["preopanc"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Professor of Pancreatic and Hepatobiliary Surgery, Amsterdam UMC","institutionId":"amsterdam-umc","specialisms":["Pancreatic surgery","Neoadjuvant therapy","Minimally invasive pancreatectomy","Surgical trials"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Besselink%20MG%5BAuthor%5D%20pancreatic%20PREOPANC"}],"papers":[{"title":"Preoperative chemoradiotherapy versus immediate surgery for resectable and borderline resectable pancreatic cancer: results of the Dutch randomized phase III PREOPANC trial","journal":"JCO","year":2020,"doi":"10.1200/JCO.19.02274"},{"title":"Neoadjuvant chemoradiotherapy versus upfront surgery for resectable and borderline resectable pancreatic cancer: long-term results of the Dutch randomized PREOPANC trial","journal":"JCO","year":2022,"doi":"10.1200/JCO.21.02233"}],"orcid":"0000-0003-2650-9350"},"route":"/people/marc-besselink/","neighbours":{"cancer":[{"id":"borderline-resectable-pdac","kind":"cancer","name":"Borderline resectable pancreatic ductal adenocarcinoma","route":"/cancers/borderline-resectable-pdac/"},{"id":"ipmn-cystic-precursors","kind":"cancer","name":"Intraductal papillary mucinous neoplasm and other pancreatic cystic precursors","route":"/cancers/ipmn-cystic-precursors/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"},{"id":"resectable-pdac","kind":"cancer","name":"Resectable pancreatic ductal adenocarcinoma","route":"/cancers/resectable-pdac/"}],"technology":[{"id":"robotic-surgery","kind":"technology","name":"Robotic & minimally invasive surgery","route":"/technologies/robotic-surgery/"}],"institution":[{"id":"amsterdam-umc","kind":"institution","name":"Amsterdam UMC / Cancer Center Amsterdam","route":"/institutions/amsterdam-umc/"}],"trial":[{"id":"preopanc","kind":"trial","name":"PREOPANC-1","route":"/trials/preopanc/"},{"id":"preopanc-2","kind":"trial","name":"PREOPANC-2","route":"/trials/preopanc-2/"}],"paper":[{"id":"paper-preopanc-2-neoadjuvant-folfirinox-vs-chemoradiotherapy-lancet-oncol-2025","kind":"paper","name":"Neoadjuvant FOLFIRINOX versus neoadjuvant gemcitabine-based chemoradiotherapy in resectable and borderline resectable pancreatic cancer (PREOPANC-2): a multicentre, open-label, phase 3 randomised trial","route":"/key-papers/paper-preopanc-2-neoadjuvant-folfirinox-vs-chemoradiotherapy-lancet-oncol-2025/"},{"id":"paper-preopanc-preoperative-chemoradiotherapy-jco-2020","kind":"paper","name":"Preoperative Chemoradiotherapy Versus Immediate Surgery for Resectable and Borderline Resectable Pancreatic Cancer: Results of the Dutch Randomized Phase III PREOPANC Trial","route":"/key-papers/paper-preopanc-preoperative-chemoradiotherapy-jco-2020/"}],"roadmap":[{"id":"pancreatic-roadmap","kind":"roadmap","name":"Pancreatic cancer roadmap: from Whipple's operation to gemcitabine, FOLFIRINOX, adjuvant chemotherapy, PARP inhibition, KRAS inhibition, vaccines and the surveillance question","route":"/roadmaps/pancreatic-roadmap/"}]}}