{"entity":{"id":"malachi-griffith","kind":"person","name":"Malachi Griffith","aka":[],"tldr":"Co-created CIViC, the open database of what cancer mutations mean, and the pVACtools neoantigen pipeline.","summary":"Malachi Griffith is Associate Professor of Medicine and Genetics and Assistant Director of the McDonnell Genome Institute at Siteman Cancer Center, Washington University. With Obi Griffith he co-created CIViC, the open community database of what cancer mutations mean, and the pVACtools neoantigen prediction pipeline. His selected paper describes CIViC as a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer. He now designs personalised neoantigen vaccine trials at WashU and continues to work on clinical genomics.","asOf":"2026-09-08","links":[{"label":"Griffith lab","url":"https://griffithlab.org"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Griffith%20M%5BAuthor%5D"}],"tags":[],"related":[],"cancers":[],"sections":[],"technologies":["cgp","neoantigen-mrna-vaccine"],"targets":[],"drugs":[],"companies":[],"institutions":["wustl-siteman"],"pathways":[],"terms":["neoantigen"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["nature-genetics"],"dependsOn":[],"notes":[],"role":"Associate Professor of Medicine and Genetics; Assistant Director, McDonnell Genome Institute","institutionId":"wustl-siteman","specialisms":["Clinical genomics","CIViC knowledge base","Neoantigen prediction"],"profiles":[{"label":"Griffith lab","url":"https://griffithlab.org"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Griffith%20M%5BAuthor%5D"}],"papers":[{"title":"CIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer","journal":"Nature Genetics","year":2017,"url":"https://doi.org/10.1038/ng.3774","doi":"10.1038/ng.3774"}]},"route":"/people/malachi-griffith/","neighbours":{"technology":[{"id":"cgp","kind":"technology","name":"Comprehensive genomic profiling","route":"/technologies/cgp/"},{"id":"neoantigen-mrna-vaccine","kind":"technology","name":"Personalised neoantigen (mRNA) vaccines","route":"/technologies/neoantigen-mrna-vaccine/"}],"institution":[{"id":"wustl-siteman","kind":"institution","name":"Siteman Cancer Center, Washington University","route":"/institutions/wustl-siteman/"}],"term":[{"id":"neoantigen","kind":"term","name":"Neoantigen","route":"/terms/neoantigen/"}],"journal":[{"id":"nature-genetics","kind":"journal","name":"Nature Genetics","route":"/journals/nature-genetics/"}]}}