{"entity":{"id":"lu-you","kind":"person","name":"You Lu","aka":[],"tldr":"Ran the first clinical trial of CRISPR-edited T cells in humans, in patients with lung cancer.","summary":"You Lu is Professor of Thoracic Oncology at West China Hospital, Sichuan University, where he leads thoracic oncology. He ran the first clinical trial of CRISPR-edited T cells in humans, a first-in-human study of PD-1-edited T cells in patients with lung cancer, alongside research in lung cancer radiotherapy and immunotherapy. His publications include the report on the safety and feasibility of CRISPR-edited T cells in patients with refractory non-small-cell lung cancer. His interests are lung cancer, radiation oncology, CRISPR-edited and engineered T cells, and immunotherapy.","asOf":"2026-09-08","links":[{"label":"West China Hospital","url":"https://www.wchscu.cn"},{"label":"PubMed author search","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Lu%20Y%5BAuthor%5D%20West%20China%20CRISPR%20PD-1%20T%20cells"}],"tags":[],"related":[],"cancers":["nsclc"],"sections":[],"technologies":["car-t","tcr-t","crispr-screens"],"targets":["pd1"],"drugs":[],"companies":[],"institutions":["west-china"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Professor of Thoracic Oncology, West China Hospital, Sichuan University","institutionId":"west-china","specialisms":["Lung cancer","Radiation oncology","CRISPR-edited T cells","Immunotherapy"],"profiles":[{"label":"West China Hospital","url":"https://www.wchscu.cn"},{"label":"PubMed author search","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Lu%20Y%5BAuthor%5D%20West%20China%20CRISPR%20PD-1%20T%20cells"}],"papers":[{"title":"Safety and feasibility of CRISPR-edited T cells in patients with refractory non-small-cell lung cancer","journal":"Nature Medicine","year":2020,"doi":"10.1038/s41591-020-0840-5"}],"orcid":"0000-0001-5761-3121"},"route":"/people/lu-you/","neighbours":{"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"technology":[{"id":"car-t","kind":"technology","name":"CAR-T cell therapy","route":"/technologies/car-t/"},{"id":"crispr-screens","kind":"technology","name":"CRISPR functional genomics","route":"/technologies/crispr-screens/"},{"id":"tcr-t","kind":"technology","name":"TCR-T cell therapy","route":"/technologies/tcr-t/"}],"target":[{"id":"pd1","kind":"target","name":"PD-1","route":"/targets/pd1/"}],"institution":[{"id":"west-china","kind":"institution","name":"West China Hospital, Sichuan University","route":"/institutions/west-china/"}]}}