{"entity":{"id":"lrp1b","kind":"target","name":"LRP1B","aka":["LDL receptor related protein 1B","Low-density lipoprotein receptor-related protein 1B","LRP-DIT","LRPDIT"],"tldr":"LRP1B (Low-density lipoprotein receptor-related protein 1B) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Lung cancer, Prostate cancer, Pancreatic ductal adenocarcinoma and 5 more.","summary":"Potential cell surface proteins that bind and internalise ligands in the process of receptor-mediated endocytosis.\n\nCIViC holds 4 clinical evidence items and 0 assertions across 4 variants, naming Immune Checkpoint Inhibitor and Doxorubicin. Open Targets scores its association with cancer at 0.77 (direct and indirect evidence; datatypes literature 0.97, affected pathway 0.76, genetic association 0.44, somatic mutation 0.88). IntOGen calls it a driver in 70 cohorts (39 activating, 27 loss-of-function), covering Acute Myeloid Leukaemia, Basal Cell Carcinoma, Invasive Breast Carcinoma, Renal Clear Cell Carcinoma, Cholangiocarcinoma, Chronic Lymphocytic Leukaemia/Small Lymphocytic Lymphoma and others.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6693","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6693"},{"label":"UniProt Q9NZR2","url":"https://www.uniprot.org/uniprotkb/Q9NZR2/entry"},{"label":"NCBI Gene 53353","url":"https://www.ncbi.nlm.nih.gov/gene/53353"},{"label":"Ensembl ENSG00000168702","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000168702"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["lung-cancer","prostate","pancreatic","skin-cancer","esophageal","breast-cancer","colorectal","head-and-neck"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; IntOGen calls it an activating (Act) driver in 39 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 27 cohorts; CIViC holds 4 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"LRP1B","role":["drug-target","oncogene-driver","tumour-suppressor","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:6693","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6693","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9NZR2","url":"https://www.uniprot.org/uniprotkb/Q9NZR2/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene LRP1B","url":"https://civicdb.org/features/12146","note":"4 evidence items, 0 assertions, 4 variants; diseases: Glioblastoma, Ovarian Cancer, Lung Adenocarcinoma, Solid Tumour (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000168702","url":"https://platform.opentargets.org/target/ENSG00000168702/associations","note":"association with cancer (MONDO_0004992) 0.77; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.62, gastric cancer 0.55, oesophageal cancer 0.53, prostate cancer 0.56, ovarian cancer 0.55, melanoma 0.66 (GraphQL API, CC0)"},{"label":"IntOGen LRP1B","url":"https://www.intogen.org/search?gene=LRP1B","note":"driver in 70 cohorts (Act 39, LoF 27); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"specificity":"tumour-specific","distribution":"many-types","specificityNote":"Tumour-specific alteration: the catalogues call it an oncogene driver (IntOGen cohort analysis finds it activated more often than chance) and a tumour suppressor (IntOGen finds it knocked out more often than chance), so the direction differs between cohorts but the alteration is somatic either way; what a medicine would aim at or exploit is the altered form or its loss, absent from normal cells; no corpus medicine is aimed at it yet. HPA LRP1B: RNA tissue enhanced (brain 9 nTPM, thyroid gland 5 nTPM); no normal tissue stained high; highest cancer staining liver cancer (5 of 11 high). Distribution: 8 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Lung cancer (all types), Prostate cancer, Pancreatic ductal adenocarcinoma, Skin cancer (all types), Oesophageal cancer, Breast cancer (all types), Colorectal cancer and more); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 6 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"UniProt Q9NZR2","url":"https://www.uniprot.org/uniprotkb/Q9NZR2/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene LRP1B","url":"https://civicdb.org/features/12146","note":"4 evidence items, 0 assertions, 4 variants; diseases: Glioblastoma, Ovarian Cancer, Lung Adenocarcinoma, Solid Tumour (GraphQL API, CC0)"},{"label":"IntOGen LRP1B","url":"https://www.intogen.org/search?gene=LRP1B","note":"driver in 70 cohorts (Act 39, LoF 27); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"},{"label":"Human Protein Atlas LRP1B tissue","url":"https://www.proteinatlas.org/ENSG00000168702-LRP1B/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000168702 associations","url":"https://platform.opentargets.org/target/ENSG00000168702/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:6693","ensembl":"ENSG00000168702","uniprot":"Q9NZR2","entrez":"53353","firstDescribed":2000,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Liu C.-X. et al, Cancer Res, 2000, \"LRP-DIT, a putative endocytic receptor gene, is frequently inactivated in non-small cell lung cancer cell lines\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/10766186/","biology":"Potential cell surface proteins that bind and internalise ligands in the process of receptor-mediated endocytosis. Location: Membrane (UniProt). Locus 2q22.1-q22.2 (HGNC).","whereFound":["Lung cancer: Open Targets association 0.67 with lung cancer (MONDO_0008903)","Prostate cancer: Open Targets association 0.56 with prostate cancer (MONDO_0008315); IntOGen driver in 7 cohorts (PRAD)","Pancreatic ductal adenocarcinoma: IntOGen driver in 5 cohorts (PAAD, PANCREAS)","Skin cancer: Open Targets association 0.64 with skin cancer (MONDO_0002898); IntOGen driver in 1 cohort (SKIN)","Oesophageal cancer: Open Targets association 0.53 with oesophageal cancer (MONDO_0007576); IntOGen driver in 4 cohorts (ESCA)","Breast cancer: Open Targets association 0.59 with breast cancer (MONDO_0007254); IntOGen driver in 4 cohorts (BRCA)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/lrp1b/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"esophageal","kind":"cancer","name":"Oesophageal cancer","route":"/cancers/esophageal/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}