{"entity":{"id":"louis-chesler","kind":"person","name":"Louis Chesler","aka":[],"tldr":"Paediatric oncologist and neuroblastoma researcher who leads Children's Cancer Institute in Sydney, Australia's dedicated childhood cancer research institute.","summary":"Professor Louis Chesler is Executive Director of Children's Cancer Institute (CCI) in Sydney, which partners with the Sydney Children's Hospitals Network on paediatric oncology research and the Zero Childhood Cancer precision medicine programme. He is a paediatric oncologist whose laboratory research focuses on MYCN-driven neuroblastoma and paediatric brain tumours and on developing targeted therapies for children. He previously led paediatric solid tumour biology at The Institute of Cancer Research, London.","asOf":"2026-09-10","links":[{"label":"Institution profile","url":"https://www.ccia.org.au/about-cci/our-people"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Chesler+L%5BAuthor%5D"}],"tags":["leadership","clinician-scientist","paediatric oncology","neuroblastoma"],"related":[],"cancers":["neuroblastoma","medulloblastoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["sydney-childrens-hospitals-network"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Executive Director, Children's Cancer Institute","institutionId":"sydney-childrens-hospitals-network","specialisms":["Paediatric oncology","Neuroblastoma","Paediatric drug development"],"profiles":[{"label":"Institution profile","url":"https://www.ccia.org.au/about-cci/our-people"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Chesler+L%5BAuthor%5D"}],"papers":[{"title":"Inhibition of Phosphatidylinositol 3-Kinase Destabilizes Mycn Protein and Blocks Malignant Progression in Neuroblastoma","journal":"Cancer Research","year":2006,"doi":"10.1158/0008-5472.can-05-2769"},{"title":"Small Molecule Inhibitors of Aurora-A Induce Proteasomal Degradation of N-Myc in Childhood Neuroblastoma","journal":"Cancer Cell","year":2013,"doi":"10.1016/j.ccr.2013.05.005"},{"title":"Targeting MYCN and ALK in resistant and relapsing neuroblastoma","journal":"Cancer Drug Resistance","year":2019,"doi":"10.20517/cdr.2019.009"}]},"route":"/people/louis-chesler/","neighbours":{"cancer":[{"id":"medulloblastoma","kind":"cancer","name":"Medulloblastoma","route":"/cancers/medulloblastoma/"},{"id":"neuroblastoma","kind":"cancer","name":"Neuroblastoma (paediatric)","route":"/cancers/neuroblastoma/"}],"institution":[{"id":"sydney-childrens-hospitals-network","kind":"institution","name":"Sydney Children's Hospitals Network / Children's Cancer Institute","route":"/institutions/sydney-childrens-hospitals-network/"}]}}