{"entity":{"id":"lmo7","kind":"target","name":"LMO7","aka":["LIM domain 7","LIM domain only protein 7","FBX20","KIAA0858","FBXO20"],"tldr":"LMO7 (LIM domain only protein 7) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"UniProt has no function text for Q8WWI1; HGNC names it \"LIM domain 7\".\n\nOpen Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.45, affected pathway 0.76, animal model 0.80, genetic association 0.48).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6646","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6646"},{"label":"UniProt Q8WWI1","url":"https://www.uniprot.org/uniprotkb/Q8WWI1/entry"},{"label":"NCBI Gene 4008","url":"https://www.ncbi.nlm.nih.gov/gene/4008"},{"label":"Ensembl ENSG00000136153","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000136153"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"LMO7","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:6646","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6646","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8WWI1","url":"https://www.uniprot.org/uniprotkb/Q8WWI1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000136153","url":"https://platform.opentargets.org/target/ENSG00000136153/associations","note":"association with cancer (MONDO_0004992) 0.57;  (GraphQL API, CC0)"}],"specificitySources":[],"hgnc":"HGNC:6646","ensembl":"ENSG00000136153","uniprot":"Q8WWI1","entrez":"4008","firstDescribed":1998,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1998, \"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/10048485/","biology":"UniProt has no function text for Q8WWI1; HGNC names it \"LIM domain 7\". Locus 13q22.2 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/lmo7/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}