{"entity":{"id":"liver-directed-therapy","kind":"term","name":"Liver-directed therapy (TACE, TARE, HAI, ablation)","aka":["liver-directed","liver-directed therapy","liver-directed treatment","locoregional treatment","locoregional therapies","hepatic arterial infusion","HAI","HAI pump","hepatic artery infusion","intra-arterial","intra-arterial chemotherapy","hepatic-dominant","liver-dominant","liver-limited","liver-confined","intrahepatic"],"tldr":"The set of treatments aimed only at tumours in the liver, delivered through its artery or by needle, used when the liver is the main or only site of disease: chemoembolisation, radioactive beads, ablation and infusion pumps.","summary":"Because the liver is a common and often the sole site of spread (colorectal cancer, uveal melanoma, neuroendocrine tumours) and the primary site of hepatocellular carcinoma, treating it locally can control disease for years. Options are resection and ablation for limited disease, TACE and radioembolisation for multifocal disease, hepatic arterial infusion of floxuridine via an implanted pump (MSK, PUMP trial) for colorectal metastases, percutaneous hepatic perfusion (chemosaturation) for uveal melanoma metastases, and SBRT or proton therapy for lesions near vessels. They are increasingly combined with systemic therapy, and trials test sequencing rather than replacement.","asOf":"2026-09-09","wikipedia":"https://en.wikipedia.org/wiki/Liver_cancer#Treatment","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Liver_cancer#Treatment"}],"tags":[],"related":["tace","tare","hepatectomy","radiofrequency-ablation"],"cancers":["hcc","colorectal","melanoma","neuroendocrine"],"sections":["surgery","radiopharma"],"technologies":["percutaneous-hepatic-perfusion","thermal-ablation"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Treatment jargon"},"route":"/terms/liver-directed-therapy/","neighbours":{"technology":[{"id":"percutaneous-hepatic-perfusion","kind":"technology","name":"Percutaneous hepatic perfusion (chemosaturation)","route":"/technologies/percutaneous-hepatic-perfusion/"},{"id":"thermal-ablation","kind":"technology","name":"Thermal ablation (RFA, microwave, cryo)","route":"/technologies/thermal-ablation/"},{"id":"tace","kind":"technology","name":"Transarterial chemoembolisation (TACE)","route":"/technologies/tace/"}],"term":[{"id":"hepatectomy","kind":"term","name":"Hepatectomy (liver resection)","route":"/terms/hepatectomy/"},{"id":"intraperitoneal-chemotherapy","kind":"term","name":"Intraperitoneal (IP) chemotherapy","route":"/terms/intraperitoneal-chemotherapy/"},{"id":"radiofrequency-ablation","kind":"term","name":"Radiofrequency ablation (RFA)","route":"/terms/radiofrequency-ablation/"},{"id":"tace-term","kind":"term","name":"TACE (transarterial chemoembolisation)","route":"/terms/tace-term/"},{"id":"tare","kind":"term","name":"TARE / SIRT (radioembolisation with yttrium-90)","route":"/terms/tare/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"grade-3-net","kind":"cancer","name":"Grade 3 well-differentiated neuroendocrine tumour","route":"/cancers/grade-3-net/"},{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"neuroendocrine","kind":"cancer","name":"Neuroendocrine tumours","route":"/cancers/neuroendocrine/"},{"id":"pancreatic-net","kind":"cancer","name":"Pancreatic neuroendocrine tumours","route":"/cancers/pancreatic-net/"},{"id":"small-intestinal-net","kind":"cancer","name":"Small intestinal neuroendocrine tumours","route":"/cancers/small-intestinal-net/"}],"section":[{"id":"radiopharma","kind":"section","name":"Radiopharmaceuticals & Theranostics","route":"/fronts/radiopharma/"},{"id":"surgery","kind":"section","name":"Surgery & Interventional","route":"/fronts/surgery/"}]}}