{"entity":{"id":"linda-mileshkin","kind":"person","name":"Linda Mileshkin","aka":[],"tldr":"Led OUTBACK, which showed adding chemotherapy after chemoradiation does not help cervical cancer, a key negative result.","summary":"Linda Mileshkin was principal investigator of OUTBACK, the ANZGOG-led international trial showing that adjuvant carboplatin-paclitaxel after chemoradiotherapy does not improve survival in locally advanced cervical cancer, sparing patients unnecessary toxicity. She also leads the CUPISCO and other trials in cancer of unknown primary and directs clinical trials at Peter Mac.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Mileshkin%20L%5BAuthor%5D%20cervical%20OUTBACK"}],"tags":["cervical","australia","cooperative-group"],"related":[],"cancers":["cervical","cancer-of-unknown-primary"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["peter-mac"],"pathways":[],"terms":[],"trials":["outback"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Medical Oncologist and Director of Clinical Trials, Peter MacCallum Cancer Centre","institutionId":"peter-mac","specialisms":["Cervical cancer","Gynaecologic oncology","Cancer of unknown primary","Cooperative-group trials"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Mileshkin%20L%5BAuthor%5D%20cervical%20OUTBACK"}],"papers":[{"title":"Adjuvant chemotherapy following chemoradiotherapy as primary treatment for locally advanced cervical cancer versus chemoradiotherapy alone (OUTBACK)","journal":"Lancet Oncology","year":2023,"doi":"10.1016/S1470-2045(23)00147-X"},{"title":"Cancer of unknown primary: challenges and progress in clinical management","journal":"Lancet Oncology","year":2018}],"orcid":"0000-0001-6826-6014"},"route":"/people/linda-mileshkin/","neighbours":{"cancer":[{"id":"cancer-of-unknown-primary","kind":"cancer","name":"Cancer of unknown primary (CUP)","route":"/cancers/cancer-of-unknown-primary/"},{"id":"cervical","kind":"cancer","name":"Cervical cancer","route":"/cancers/cervical/"}],"institution":[{"id":"peter-mac","kind":"institution","name":"Peter MacCallum Cancer Centre","route":"/institutions/peter-mac/"}],"trial":[{"id":"cupisco","kind":"trial","name":"CUPISCO","route":"/trials/cupisco/"},{"id":"outback","kind":"trial","name":"OUTBACK / ANZGOG 0902 / GOG-0274","route":"/trials/outback/"}]}}