{"entity":{"id":"limb-salvage-term","kind":"term","name":"Limb-salvage surgery","aka":["limb-salvage","limb salvage","limb-sparing surgery","endoprosthetic reconstruction"],"tldr":"Removing a bone or soft-tissue sarcoma while keeping the arm or leg, rebuilding the bone with a metal endoprosthesis or a graft.","summary":"Rosenberg's NCI trial and the arrival of effective chemotherapy made limb salvage standard for osteosarcoma and Ewing sarcoma in the 1980s, with survival equal to amputation. Wide margins are still required; radiotherapy adds local control for soft-tissue sarcomas. Growing endoprostheses for children, computer-navigated resection and 3D-printed implants are current refinements; infection and mechanical failure of the prosthesis are the long-term problems.","asOf":"2026-09-09","wikipedia":"https://en.wikipedia.org/wiki/Limb-sparing_techniques","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Limb-sparing_techniques"}],"tags":[],"related":["limb-salvage-surgery","resection-margins","wide-local-excision"],"cancers":["sarcoma"],"sections":["surgery"],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Procedures"},"route":"/terms/limb-salvage-term/","neighbours":{"technology":[{"id":"rejuv-recon-limb","kind":"technology","name":"Limb salvage, amputation, and the rehabilitation that follows either","route":"/technologies/rejuv-recon-limb/"},{"id":"limb-salvage-surgery","kind":"technology","name":"Limb-salvage surgery and endoprosthetic reconstruction","route":"/technologies/limb-salvage-surgery/"}],"term":[{"id":"resection-margins","kind":"term","name":"Resection margins (R0 / R1 / R2)","route":"/terms/resection-margins/"},{"id":"wide-local-excision","kind":"term","name":"Wide local excision","route":"/terms/wide-local-excision/"}],"cancer":[{"id":"osteosarcoma","kind":"cancer","name":"Osteosarcoma","route":"/cancers/osteosarcoma/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"}],"section":[{"id":"surgery","kind":"section","name":"Surgery & Interventional","route":"/fronts/surgery/"}],"drug":[{"id":"tasonermin","kind":"drug","name":"Tasonermin","route":"/drugs/tasonermin/"}]}}