{"entity":{"id":"lillian-siu","kind":"person","name":"Lillian L. Siu","aka":[],"tldr":"Runs one of the world's largest phase 1 programmes and led trials that shaped head and neck cancer immunotherapy.","summary":"Lillian L. Siu is Director of the Phase I Program and holds the BMO Chair in Precision Cancer Genomics at the Princess Margaret Cancer Centre. She is a medical oncologist who runs one of the world's largest phase 1 programmes and led KEYNOTE and other immunotherapy studies that shaped head and neck cancer treatment. Her selected paper reports the CONDOR trial of durvalumab with or without tremelimumab in PD-L1-low or negative recurrent or metastatic head and neck squamous cell carcinoma. She pioneers ctDNA-guided early trials and is AACR president for 2025 to 2026.","asOf":"2026-09-08","wikipedia":"https://en.wikipedia.org/wiki/Lillian_Siu","links":[{"label":"UHN profile","url":"https://www.uhnresearch.ca/researcher/lillian-l-siu"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Siu%20LL%5BAuthor%5D"}],"tags":[],"related":[],"cancers":["head-and-neck"],"sections":[],"technologies":["liquid-biopsy","checkpoint-inhibitor"],"targets":[],"drugs":[],"companies":[],"institutions":["princess-margaret"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Director, Phase I Program; BMO Chair in Precision Cancer Genomics","institutionId":"princess-margaret","specialisms":["Early drug development","Head and neck cancer","Immunotherapy","ctDNA"],"profiles":[{"label":"UHN profile","url":"https://www.uhnresearch.ca/researcher/lillian-l-siu"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Siu%20LL%5BAuthor%5D"}],"papers":[{"title":"Safety and efficacy of durvalumab with or without tremelimumab in patients with PD-L1-low/negative recurrent or metastatic HNSCC (CONDOR)","journal":"JAMA Oncology","year":2019,"url":"https://doi.org/10.1001/jamaoncol.2018.4628","doi":"10.1001/jamaoncol.2018.4628"}]},"route":"/people/lillian-siu/","neighbours":{"cancer":[{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"}],"technology":[{"id":"checkpoint-inhibitor","kind":"technology","name":"Immune checkpoint inhibitors","route":"/technologies/checkpoint-inhibitor/"},{"id":"liquid-biopsy","kind":"technology","name":"Liquid biopsy (ctDNA)","route":"/technologies/liquid-biopsy/"}],"institution":[{"id":"princess-margaret","kind":"institution","name":"Princess Margaret Cancer Centre","route":"/institutions/princess-margaret/"}]}}