{"entity":{"id":"lgr5","kind":"term","name":"LGR5","aka":[],"tldr":"A marker of stem cells in the gut and of stem-like cells in tumours, used to aim drugs at the cells that regrow a cancer.","summary":"LGR5, leucine-rich repeat-containing G-protein-coupled receptor 5, is a Wnt target gene that marks intestinal stem cells and stem-like cells in tumours, the cells thought to regrow a cancer after treatment. In head and neck squamous cell carcinoma and colorectal cancer it is being used to aim drugs at those cells: petosemtamab binds LGR5 and uses that binding to degrade EGFR selectively in tumour cells, and LGR5-directed antibody-drug conjugates have also been explored. Readers meet the term on the petosemtamab drug page, in the LiGeR-HN1 trial and within the Wnt and beta-catenin pathway. It is also part of the wider story of cancer stem cells and phenotypic plasticity.","asOf":"2026-09-07","wikipedia":"https://en.wikipedia.org/wiki/LGR5","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/LGR5"}],"tags":[],"related":[],"cancers":["head-and-neck","colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":["petosemtamab"],"companies":[],"institutions":[],"pathways":["wnt"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Cancer biology"},"route":"/terms/lgr5/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"}],"drug":[{"id":"petosemtamab","kind":"drug","name":"Petosemtamab","route":"/drugs/petosemtamab/"}],"pathway":[{"id":"cancer-stem-cells-plasticity","kind":"pathway","name":"Cancer stem cells & phenotypic plasticity","route":"/pathways/cancer-stem-cells-plasticity/"},{"id":"wnt","kind":"pathway","name":"Wnt / β-catenin","route":"/pathways/wnt/"}],"trial":[{"id":"liger-hn1","kind":"trial","name":"LiGeR-HN1","route":"/trials/liger-hn1/"}]}}