{"entity":{"id":"lars-zender","kind":"person","name":"Lars Zender","aka":[],"tldr":"Medical oncologist and cancer biologist at Tübingen, known for work on senescence surveillance and functional genomics in liver cancer.","summary":"Prof. Lars Zender is Deputy Speaker of the CCC Tübingen-Stuttgart and Medical Director of Internal Medicine VIII (Medical Oncology and Pulmonology) at Tübingen University Hospital. His laboratory uses mouse models and in vivo RNAi/CRISPR screens to study hepatocellular carcinoma and the immune surveillance of senescent pre-malignant cells, and he has received the Gottfried Wilhelm Leibniz Prize.","asOf":"2026-09-10","links":[{"label":"Institution profile","url":"https://www.medizin.uni-tuebingen.de/de/das-klinikum/einrichtungen/zentren/tumorzentrum-ccc/vorstand"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Zender+L%5BAuthor%5D"}],"tags":["leadership","clinician-scientist","liver cancer","cancer biology"],"related":[],"cancers":["hcc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["ccc-tuebingen"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Deputy Speaker; Medical Director, Internal Medicine VIII (Medical Oncology and Pulmonology)","institutionId":"ccc-tuebingen","specialisms":["Medical oncology","Liver cancer biology","Senescence and tumour surveillance"],"profiles":[{"label":"Institution profile","url":"https://www.medizin.uni-tuebingen.de/de/das-klinikum/einrichtungen/zentren/tumorzentrum-ccc/vorstand"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Zender+L%5BAuthor%5D"}],"papers":[{"title":"Senescence surveillance of pre-malignant hepatocytes limits liver cancer development","journal":"Nature","year":2011,"doi":"10.1038/nature10599"},{"title":"Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression","journal":"Cancer Cell","year":2016,"doi":"10.1016/j.ccell.2016.09.003"},{"title":"Identification and Validation of Oncogenes in Liver Cancer Using an Integrative Oncogenomic Approach","journal":"Cell","year":2006,"doi":"10.1016/j.cell.2006.05.030"}]},"route":"/people/lars-zender/","neighbours":{"cancer":[{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"}],"institution":[{"id":"ccc-tuebingen","kind":"institution","name":"Comprehensive Cancer Center Tübingen-Stuttgart","route":"/institutions/ccc-tuebingen/"},{"id":"dnpm","kind":"institution","name":"Deutsches Netzwerk für Personalisierte Medizin","route":"/institutions/dnpm/"}]}}